Vertical Transmission and Neonatal Outcomes Following Maternal SARS-CoV-2 Infection During Pregnancy

Margaret H. Kyle; Maha Hussain; Victoria Saltz; Isabelle Mollicone; Mary Bence; Dani Dumitriu

doi:10.1097/GRF.0000000000000667

Vertical Transmission and Neonatal Outcomes Following Maternal SARS-CoV-2 Infection During Pregnancy

Margaret H. Kyle, Maha Hussain, Victoria Saltz, Isabelle Mollicone, Mary Bence, Dani Dumitriu

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 200 million people worldwide and has likely exposed millions of neonates to SARS-CoV-2 in utero. A large body of literature has examined the possibility of vertical transmission from pregnant women infected with SARS-CoV-2 to their neonates. In this chapter, we review mechanisms of- and evidence for-vertical transmission of SARS-CoV-2, including transplacental, through other biospecimens and breastfeeding, and discuss neonatal outcomes following in utero exposure. Based on the available literature, we conclude vertical transmission of SARS-CoV-2 is rare, and exposed neonates generally show favorable health outcomes.

Original language	English
Pages (from-to)	195-202
Number of pages	8
Journal	Clinical Obstetrics and Gynecology
Volume	65
Issue number	1
DOIs	https://doi.org/10.1097/GRF.0000000000000667
State	Published - 1 Mar 2022
Externally published	Yes

Keywords

Breastfeeding
COVID-19
Neonatal
Pregnancy
SARS-CoV-2
Vertical transmission

Access to Document

10.1097/GRF.0000000000000667

Cite this

@article{bad7f67018274053a5e303bbf711bf31,

title = "Vertical Transmission and Neonatal Outcomes Following Maternal SARS-CoV-2 Infection During Pregnancy",

abstract = "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 200 million people worldwide and has likely exposed millions of neonates to SARS-CoV-2 in utero. A large body of literature has examined the possibility of vertical transmission from pregnant women infected with SARS-CoV-2 to their neonates. In this chapter, we review mechanisms of- and evidence for-vertical transmission of SARS-CoV-2, including transplacental, through other biospecimens and breastfeeding, and discuss neonatal outcomes following in utero exposure. Based on the available literature, we conclude vertical transmission of SARS-CoV-2 is rare, and exposed neonates generally show favorable health outcomes.",

keywords = "Breastfeeding, COVID-19, Neonatal, Pregnancy, SARS-CoV-2, Vertical transmission",

author = "Kyle, {Margaret H.} and Maha Hussain and Victoria Saltz and Isabelle Mollicone and Mary Bence and Dani Dumitriu",

year = "2022",

month = mar,

day = "1",

doi = "10.1097/GRF.0000000000000667",

language = "English",

volume = "65",

pages = "195--202",

journal = "Clinical Obstetrics and Gynecology",

issn = "0009-9201",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "1",

}

TY - JOUR

T1 - Vertical Transmission and Neonatal Outcomes Following Maternal SARS-CoV-2 Infection During Pregnancy

AU - Kyle, Margaret H.

AU - Hussain, Maha

AU - Saltz, Victoria

AU - Mollicone, Isabelle

AU - Bence, Mary

AU - Dumitriu, Dani

PY - 2022/3/1

Y1 - 2022/3/1

N2 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 200 million people worldwide and has likely exposed millions of neonates to SARS-CoV-2 in utero. A large body of literature has examined the possibility of vertical transmission from pregnant women infected with SARS-CoV-2 to their neonates. In this chapter, we review mechanisms of- and evidence for-vertical transmission of SARS-CoV-2, including transplacental, through other biospecimens and breastfeeding, and discuss neonatal outcomes following in utero exposure. Based on the available literature, we conclude vertical transmission of SARS-CoV-2 is rare, and exposed neonates generally show favorable health outcomes.

AB - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 200 million people worldwide and has likely exposed millions of neonates to SARS-CoV-2 in utero. A large body of literature has examined the possibility of vertical transmission from pregnant women infected with SARS-CoV-2 to their neonates. In this chapter, we review mechanisms of- and evidence for-vertical transmission of SARS-CoV-2, including transplacental, through other biospecimens and breastfeeding, and discuss neonatal outcomes following in utero exposure. Based on the available literature, we conclude vertical transmission of SARS-CoV-2 is rare, and exposed neonates generally show favorable health outcomes.

KW - Breastfeeding

KW - COVID-19

KW - Neonatal

KW - Pregnancy

KW - SARS-CoV-2

KW - Vertical transmission

UR - http://www.scopus.com/inward/record.url?scp=85123672741&partnerID=8YFLogxK

U2 - 10.1097/GRF.0000000000000667

DO - 10.1097/GRF.0000000000000667

M3 - Article

C2 - 35045041

AN - SCOPUS:85123672741

SN - 0009-9201

VL - 65

SP - 195

EP - 202

JO - Clinical Obstetrics and Gynecology

JF - Clinical Obstetrics and Gynecology

IS - 1

ER -

Vertical Transmission and Neonatal Outcomes Following Maternal SARS-CoV-2 Infection During Pregnancy

Abstract

Keywords

Access to Document

Fingerprint

Cite this