Vertebrate homologues of Frodo are dynamically expressed during embryonic development in tissues undergoing extensive morphogenetic movements

Nina L. Hunter, Hiroki Hikasa, Susan M. Dymecki, Sergei Y. Sokol

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Frodo has been identified as a protein interacting with Dishevelled, an essential mediator of the Wnt signaling pathway, critical for the determination of cell fate and polarity in embryonic development. In this study, we use specific gene probes to characterize stage- and tissue-specific expression patterns of the mouse Frodo homologue and compare them with Frodo expression patterns in Xenopus embryos. In situ hybridization analysis of mouse Frodo transcripts demonstrates that, similar to Xenopus Frodo, mouse Frodo is expressed in primitive streak mesoderm, neuroectoderm, neural crest, presomitic mesoderm, and somites. In many cases, Frodo expression is confined to tissues undergoing extensive morphogenesis, suggesting that Frodo may be involved in the regulation of cell shape and motility. Highly conserved dynamic expression patterns of Frodo homologues indicate a similar function for these proteins in different vertebrates.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalDevelopmental Dynamics
Volume235
Issue number1
DOIs
StatePublished - 2006

Keywords

  • Dapper
  • Frodo
  • In situ hybridization
  • Migrating cells
  • Mouse
  • Neural crest
  • Primitive streak
  • Somites
  • Wnt

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