TY - JOUR
T1 - Ventricular catheter tract hemorrhage as a risk factor for ventriculostomy-related infection
AU - Kim, Julie
AU - Lee, James
AU - Feng, Rui
AU - Chartrain, Alexander
AU - Sobotka, Stanislaw
AU - Griffiths, Stephen
AU - Weiss, Nirit
AU - Dangayach, Neha
AU - Bederson, Joshua
AU - Mayer, Stephan A.
AU - Gordon, Errol
N1 - Funding Information:
The authors would like to acknowledge Joe Marchione, a neuroradiology fellow, and Javaad Ahmad, a neurocritical care fellow, who contributed as blinded imaging readers, and Sean Neifert, who contributed as a biostatistician.
Publisher Copyright:
Copyright © 2019 by the Congress of Neurological Surgeons.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - BACKGROUND: Ventriculostomy-related infection (VRI) is a feared complication of external ventricular drain (EVD) placement. Although many contributing factors to VRI have been examined, little is known whether there is an association between ventriculostomy-related catheter tract hemorrhage (VCTH) and VRI. OBJECTIVE: To evaluate risk factors for VRI and assess possible correlations with VCTH. METHODS: We performed a retrospective analysis of patients with EVD placement in a neurocritical care unit between 2011 and 2015. VRI was defined as clinical signs of infection with a positive cerebrospinal fluid gram stain and isolation of cerebrospinal fluid culture. VCTH was diagnosed by computed tomography immediately after EVD insertion. RESULTS: A total of 247 patients with EVD were identified during the 5-yr study period. An association between VCTH and gram-negative VRI was identified (P = .02). Ten percent (25 of 247 patients) developed a VRI, and 7% (18 of 247 patients) had a VCTH. Of the 25 patients with VRI, 20% (n = 5) had a VCTH, compared to 6% (n = 13) of 222 patients who had an EVD placed but did not develop VRI. There were no significant differences in demographic and clinical factors except for multiple EVD insertions (P < .00001), EVD duration (P < .001), and hospital length of stay (P < .001). CONCLUSION: VCTH is a potentially significant risk factor for VRI. Further analysis will be needed to confirm the strength of this association, and to delineate the possible mechanisms by which tract hemorrhage may serve as a nidus for bacterial penetration into the central nervous system.
AB - BACKGROUND: Ventriculostomy-related infection (VRI) is a feared complication of external ventricular drain (EVD) placement. Although many contributing factors to VRI have been examined, little is known whether there is an association between ventriculostomy-related catheter tract hemorrhage (VCTH) and VRI. OBJECTIVE: To evaluate risk factors for VRI and assess possible correlations with VCTH. METHODS: We performed a retrospective analysis of patients with EVD placement in a neurocritical care unit between 2011 and 2015. VRI was defined as clinical signs of infection with a positive cerebrospinal fluid gram stain and isolation of cerebrospinal fluid culture. VCTH was diagnosed by computed tomography immediately after EVD insertion. RESULTS: A total of 247 patients with EVD were identified during the 5-yr study period. An association between VCTH and gram-negative VRI was identified (P = .02). Ten percent (25 of 247 patients) developed a VRI, and 7% (18 of 247 patients) had a VCTH. Of the 25 patients with VRI, 20% (n = 5) had a VCTH, compared to 6% (n = 13) of 222 patients who had an EVD placed but did not develop VRI. There were no significant differences in demographic and clinical factors except for multiple EVD insertions (P < .00001), EVD duration (P < .001), and hospital length of stay (P < .001). CONCLUSION: VCTH is a potentially significant risk factor for VRI. Further analysis will be needed to confirm the strength of this association, and to delineate the possible mechanisms by which tract hemorrhage may serve as a nidus for bacterial penetration into the central nervous system.
KW - External ventricular drain
KW - Gram-negative infections
KW - Neurocritical care unit
KW - Ventriculostomy-related catheter tract hemorrhage
KW - Ventriculostomy-related infection
UR - http://www.scopus.com/inward/record.url?scp=85076583853&partnerID=8YFLogxK
U2 - 10.1093/ons/opz148
DO - 10.1093/ons/opz148
M3 - Article
C2 - 31294451
AN - SCOPUS:85076583853
VL - 18
SP - 69
EP - 74
JO - Operative Neurosurgery
JF - Operative Neurosurgery
SN - 2332-4252
IS - 1
ER -