Ventricular assist device in children with cardiac graft failure

Iki Adachi; Francisco A. Guzmán-Pruneda; Muhammad S. Khan; E. Dean McKenzie; Charles D. Fraser

doi:10.1097/MAT.0000000000000281

Ventricular assist device in children with cardiac graft failure

Iki Adachi, Francisco A. Guzmán-Pruneda, Muhammad S. Khan, E. Dean McKenzie, Charles D. Fraser

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We sought to determine whether ventricular assist device (VAD) support is an effective therapy in children with cardiac graft dysfunction. We conducted a retrospective review of VAD usage in this scenario at our institution. Although shortterm VAD support was highly successful (89% [eight out of nine] were bridged to recovery), only 29% (2 out of 7) with long-term VAD survived to retransplant. Of note, three out of five mortalities with long-term VAD were related to sepsis (two fungal and one Gram-negative bacterial). Infectious risk imposed by ongoing immunosuppressive therapy limits the role of long-term VAD in this population.

Original language	English
Pages (from-to)	729-730
Number of pages	2
Journal	ASAIO Journal
Volume	61
Issue number	6
DOIs	https://doi.org/10.1097/MAT.0000000000000281
State	Published - 3 Nov 2015
Externally published	Yes

Keywords

Cardiac graft failure
Children
Mechanical circulatory support
Pediatric
Ventricular assist device

Access to Document

10.1097/MAT.0000000000000281

Cite this

@article{13426ec4149c43e581a7d5cfecc91bd0,

title = "Ventricular assist device in children with cardiac graft failure",

abstract = "We sought to determine whether ventricular assist device (VAD) support is an effective therapy in children with cardiac graft dysfunction. We conducted a retrospective review of VAD usage in this scenario at our institution. Although shortterm VAD support was highly successful (89% [eight out of nine] were bridged to recovery), only 29% (2 out of 7) with long-term VAD survived to retransplant. Of note, three out of five mortalities with long-term VAD were related to sepsis (two fungal and one Gram-negative bacterial). Infectious risk imposed by ongoing immunosuppressive therapy limits the role of long-term VAD in this population.",

keywords = "Cardiac graft failure, Children, Mechanical circulatory support, Pediatric, Ventricular assist device",

author = "Iki Adachi and Guzm{\'a}n-Pruneda, {Francisco A.} and Khan, {Muhammad S.} and {Dean McKenzie}, E. and Fraser, {Charles D.}",

note = "Publisher Copyright: {\textcopyright} 2015 by the American Society for Artificial Internal Organs.",

year = "2015",

month = nov,

day = "3",

doi = "10.1097/MAT.0000000000000281",

language = "English",

volume = "61",

pages = "729--730",

journal = "ASAIO Journal",

issn = "1058-2916",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "6",

}

TY - JOUR

T1 - Ventricular assist device in children with cardiac graft failure

AU - Adachi, Iki

AU - Guzmán-Pruneda, Francisco A.

AU - Khan, Muhammad S.

AU - Dean McKenzie, E.

AU - Fraser, Charles D.

PY - 2015/11/3

Y1 - 2015/11/3

N2 - We sought to determine whether ventricular assist device (VAD) support is an effective therapy in children with cardiac graft dysfunction. We conducted a retrospective review of VAD usage in this scenario at our institution. Although shortterm VAD support was highly successful (89% [eight out of nine] were bridged to recovery), only 29% (2 out of 7) with long-term VAD survived to retransplant. Of note, three out of five mortalities with long-term VAD were related to sepsis (two fungal and one Gram-negative bacterial). Infectious risk imposed by ongoing immunosuppressive therapy limits the role of long-term VAD in this population.

AB - We sought to determine whether ventricular assist device (VAD) support is an effective therapy in children with cardiac graft dysfunction. We conducted a retrospective review of VAD usage in this scenario at our institution. Although shortterm VAD support was highly successful (89% [eight out of nine] were bridged to recovery), only 29% (2 out of 7) with long-term VAD survived to retransplant. Of note, three out of five mortalities with long-term VAD were related to sepsis (two fungal and one Gram-negative bacterial). Infectious risk imposed by ongoing immunosuppressive therapy limits the role of long-term VAD in this population.

KW - Cardiac graft failure

KW - Children

KW - Mechanical circulatory support

KW - Pediatric

KW - Ventricular assist device

UR - http://www.scopus.com/inward/record.url?scp=84947018449&partnerID=8YFLogxK

U2 - 10.1097/MAT.0000000000000281

DO - 10.1097/MAT.0000000000000281

M3 - Article

C2 - 26366683

AN - SCOPUS:84947018449

SN - 1058-2916

VL - 61

SP - 729

EP - 730

JO - ASAIO Journal

JF - ASAIO Journal

IS - 6

ER -

Ventricular assist device in children with cardiac graft failure

Abstract

Keywords

Access to Document

Fingerprint

Cite this