TY - JOUR
T1 - Venous thromboembolism does not share strong familial susceptibility with coronary heart disease
T2 - A nationwide family study in Sweden
AU - Zöller, Bengt
AU - Li, Xinjun
AU - Sundquist, Jan
AU - Sundquist, Kristina
N1 - Funding Information:
This work was supported by grants to Drs Kristina and Jan Sundquist from the Swedish Research Council (2008-3110 and 2008-2638), the Swedish Council for Working Life and Social Research (2006-0386, 2007-1754 and 2007-1962) and the Swedish Research Council Formas (2006-4255-6596-99 and 2007-1352), and to Bengt Zöller from Region Skåne (124611).
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Aims This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with coronary heart disease (CHD). Methods and resultsData from the Swedish Multigeneration Register for subjects aged 076 years old for the period 19642008 were linked to the Hospital Discharge Register and Cause of Death Register. Familial risks of VTE and CHD were examined in two ways: risk of CHD in offspring whose parents had been diagnosed with VTE, and risk of VTE in offspring whose parents had been diagnosed with CHD. The analyses were repeated separately for siblings and spouses. In total, 174 768 offspring had CHD and 56 302 VTE. No association between VTE and CHD was observed among siblings. Among offspring, a lower risk of CHD was observed in subjects whose parents had suffered from VTE [standardized incidence ratio (SIR) 0.94 (95 confidence interval (CI) 0.920.95)], while offspring of parents with CHD had an increased risk of VTE [SIR 1.03 (95 CI 1.011.04)]. In spouses of VTE patients, an increased risk of CHD was observed [SIR 1.02 (95 CI 1.011.03)]. Conversely, risk of VTE was increased among spouses of CHD patients [SIR 1.03 (95 CI 1.021.03)]. Subanalyses of cases of myocardial infarction and pulmonary embolism/deep venous thrombosis showed similar results. ConclusionThe familial background of CHD is different from that of VTE. The present study suggests that it is unlikely that shared disease-causing mutations exist to a large extent in the population.
AB - Aims This nationwide study aimed to determine whether venous thromboembolism (VTE) shares familial susceptibility with coronary heart disease (CHD). Methods and resultsData from the Swedish Multigeneration Register for subjects aged 076 years old for the period 19642008 were linked to the Hospital Discharge Register and Cause of Death Register. Familial risks of VTE and CHD were examined in two ways: risk of CHD in offspring whose parents had been diagnosed with VTE, and risk of VTE in offspring whose parents had been diagnosed with CHD. The analyses were repeated separately for siblings and spouses. In total, 174 768 offspring had CHD and 56 302 VTE. No association between VTE and CHD was observed among siblings. Among offspring, a lower risk of CHD was observed in subjects whose parents had suffered from VTE [standardized incidence ratio (SIR) 0.94 (95 confidence interval (CI) 0.920.95)], while offspring of parents with CHD had an increased risk of VTE [SIR 1.03 (95 CI 1.011.04)]. In spouses of VTE patients, an increased risk of CHD was observed [SIR 1.02 (95 CI 1.011.03)]. Conversely, risk of VTE was increased among spouses of CHD patients [SIR 1.03 (95 CI 1.021.03)]. Subanalyses of cases of myocardial infarction and pulmonary embolism/deep venous thrombosis showed similar results. ConclusionThe familial background of CHD is different from that of VTE. The present study suggests that it is unlikely that shared disease-causing mutations exist to a large extent in the population.
KW - Coronary heart disease
KW - Genetics
KW - Myocardial infarction
KW - Risk factors
KW - Venous thromboembolism
UR - https://www.scopus.com/pages/publications/81855168407
U2 - 10.1093/eurheartj/ehr223
DO - 10.1093/eurheartj/ehr223
M3 - Article
C2 - 21750095
AN - SCOPUS:81855168407
SN - 0195-668X
VL - 32
SP - 2800
EP - 2805
JO - European Heart Journal
JF - European Heart Journal
IS - 22
ER -