Venous thromboembolism does not share strong familial susceptibility with pre-eclampsia/eclampsia: A nationwide family study in Sweden

B. Zöller, X. Li, J. Sundquist, K. Sundquist

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective: Genetic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of pre-eclampsia/ eclampsia (PEC/EC). This nationwide study aimed to determine whether VTE shares familial susceptibility with PEC/EC. Design Population-based cohort study. Setting: Sweden. Sample A total of 941 841 Swedish women delivering their first child between 1987 and 2008. Methods: Data from the Swedish Multigeneration Register were linked to the Swedish Hospital Discharge Register. The risk of PEC/EC was determined in primiparous women with a family history of VTE (in parents and/or siblings), compared with primiparous women without a family history of VTE. Odds ratios (ORs) were calculated by logistic regression. Main outcome measure PEC/EC in first pregnancy. Results: In total, 43 621 women had PEC/EC in association with their first pregnancy. The OR for PEC/EC in women with a family history of VTE was 1.06 (95% CI 1.01-1.11); however, a family history of VTE was associated with higher odds of PEC/EC among women with previous hypertension (OR 1.38, 95% CI 1.25-1.52). Conclusion A family history of VTE is weakly associated with PEC/EC risk, and is not clinically useful for the prediction of PEC/EC. The results of the present study suggest that it is unlikely that strong disease-causing mutations shared by VTE and PEC/EC are common in the Swedish population. The novel association between family history and PEC/EC among the subgroup with previous hypertension needs further confirmation in future studies.

Original languageEnglish
Pages (from-to)1200-1206
Number of pages7
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Volume120
Issue number10
DOIs
StatePublished - Sep 2013
Externally publishedYes

Keywords

  • Eclampsia
  • genetics
  • pre-eclampsia
  • thrombophilia
  • venous thromboembolism

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