Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)

Robert C. Kleiner; Lawrence V. Najarian; Sam Schatten; Douglas A. Jabs; Arnall Patz; Henry J. Kaplan

doi:10.1016/S0161-6420(89)32825-9

Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)

Robert C. Kleiner, Lawrence V. Najarian, Sam Schatten, Douglas A. Jabs, Arnall Patz, Henry J. Kaplan

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Abstract

The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989

Original language	English
Pages (from-to)	896-904
Number of pages	9
Journal	Ophthalmology
Volume	96
Issue number	6
DOIs	https://doi.org/10.1016/S0161-6420(89)32825-9
State	Published - 1989
Externally published	Yes

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title = "Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)",

abstract = "The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989",

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T1 - Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)

AU - Kleiner, Robert C.

AU - Najarian, Lawrence V.

AU - Schatten, Sam

AU - Jabs, Douglas A.

AU - Patz, Arnall

AU - Kaplan, Henry J.

PY - 1989

Y1 - 1989

N2 - The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989

AB - The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989

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Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)

Abstract

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