Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study.

Martyn C. Byng; Sheila A. Fisher; Cathryn M. Lewis; John C. Whittaker; Heart Study Framingham Heart Study

doi:10.1186/1471-2156-4-s1-s4

Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study.

Martyn C. Byng, Sheila A. Fisher, Cathryn M. Lewis, John C. Whittaker, Heart Study Framingham Heart Study

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3 Scopus citations

Abstract

We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.

Original language	English
Journal	BMC Genetics
Volume	4 Suppl 1
DOIs	https://doi.org/10.1186/1471-2156-4-s1-s4
State	Published - 2003
Externally published	Yes

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10.1186/1471-2156-4-s1-s4

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title = "Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study.",

abstract = "We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.",

author = "Byng, \{Martyn C.\} and Fisher, \{Sheila A.\} and Lewis, \{Cathryn M.\} and Whittaker, \{John C.\} and \{Framingham Heart Study\}, \{Heart Study\}",

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language = "English",

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journal = "BMC Genetics",

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AU - Byng, Martyn C.

AU - Fisher, Sheila A.

AU - Lewis, Cathryn M.

AU - Whittaker, John C.

AU - Framingham Heart Study, Heart Study

PY - 2003

Y1 - 2003

N2 - We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.

AB - We performed variance components linkage analysis in nuclear families from the Framingham Heart Study on nine phenotypes derived from systolic blood pressure (SBP). The phenotypes were the maximum and mean SBP, and SBP at age 40, each analyzed either uncorrected, or corrected using two subsets of epidemiological/clinical factors. Evidence for linkage to chromosome 8p was detected with all phenotypes except the uncorrected maximum SBP, suggesting this region harbors a gene contributing to variation in SBP.

UR - https://www.scopus.com/pages/publications/34248668979

U2 - 10.1186/1471-2156-4-s1-s4

DO - 10.1186/1471-2156-4-s1-s4

M3 - Article

C2 - 14975072

AN - SCOPUS:34248668979

SN - 1471-2156

VL - 4 Suppl 1

JO - BMC Genetics

JF - BMC Genetics

ER -

Variance components linkage analysis for adjusted systolic blood pressure in the Framingham Heart Study.

Abstract

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