TY - JOUR
T1 - Variables associated with familial suicide attempts in a sample of suicide attempters
AU - Baca-Garcia, Enrique
AU - Perez-Rodriguez, M. Mercedes
AU - Saiz-Gonzalez, Dolores
AU - Basurte-Villamor, Ignacio
AU - Saiz-Ruiz, Jeronimo
AU - Leiva-Murillo, José M.
AU - de Prado-Cumplido, Mario
AU - Santiago-Mozos, Ricardo
AU - Artés-Rodríguez, Antonio
AU - de Leon, Jose
N1 - Funding Information:
This study was conducted at the Hospital Ramon y Cajal, Madrid, Spain, and recruitment was supported by a National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD) Young Investigator Award to Dr. Baca-Garcia and a grant from the Spanish Health Ministry (FIS 01/0077-01), Harriet and Esteban Vicente Foundation and Conchita Rabago Foundation. Dr. Baca-Garcia is the Lilly Suicide Scholar at Columbia University. The statistical analyses described in this article were conducted without external support. The authors thank Lorraine Maw, M.A., for editorial assistance.
PY - 2007/8/15
Y1 - 2007/8/15
N2 - Attempted suicide appears to be a familial behavior. This study aims to determine the variables associated with family history of attempted suicide in a large sample of suicide attempters. The sample included 539 suicide attempters 18 years or older recruited in an emergency room. The two dichotomous dependent variables were family history of suicide attempt (10%, 51/539) and of completed suicide (4%, 23/539). Independent variables were 101 clinical variables studied with two data mining techniques: Random Forest and Forward Selection. A model for family history of completed suicide could not be developed. A classificatory model for family history of attempted suicide included the use of alcohol in the intent and family history of completed suicide (sensitivity, specificity, 98.7%; and accuracy, 96.6%). This is the first study that uses a powerful new statistical methodology, data mining, in the field of familial suicidal behaviors and suggests that it may be important to study familial variables associated with alcohol use to better understand the familiality of suicide attempts.
AB - Attempted suicide appears to be a familial behavior. This study aims to determine the variables associated with family history of attempted suicide in a large sample of suicide attempters. The sample included 539 suicide attempters 18 years or older recruited in an emergency room. The two dichotomous dependent variables were family history of suicide attempt (10%, 51/539) and of completed suicide (4%, 23/539). Independent variables were 101 clinical variables studied with two data mining techniques: Random Forest and Forward Selection. A model for family history of completed suicide could not be developed. A classificatory model for family history of attempted suicide included the use of alcohol in the intent and family history of completed suicide (sensitivity, specificity, 98.7%; and accuracy, 96.6%). This is the first study that uses a powerful new statistical methodology, data mining, in the field of familial suicidal behaviors and suggests that it may be important to study familial variables associated with alcohol use to better understand the familiality of suicide attempts.
KW - Alcohol drinking
KW - Alcohol-related disorders
KW - Attempted suicide
KW - Genetics
KW - Suicide
UR - http://www.scopus.com/inward/record.url?scp=34447548911&partnerID=8YFLogxK
U2 - 10.1016/j.pnpbp.2007.05.019
DO - 10.1016/j.pnpbp.2007.05.019
M3 - Article
C2 - 17614183
AN - SCOPUS:34447548911
VL - 31
SP - 1312
EP - 1316
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 6
ER -