TY - JOUR
T1 - Variability of response to lithium augmentation in refractory depression
AU - Price, L. H.
AU - Charney, D. S.
AU - Heninger, G. R.
PY - 1986
Y1 - 1986
N2 - Eighty-four patients with major depression refractory to a controlled antidepressant trial had lithium added to their ongoing treatment. Objective symptom ratings showed highly significant improvement in the sample as a whole. At discharge or after 24 days, 31% of the patients showed a marked response, 25% a partial response, 39% no change, and 5% an adverse response. Thus, 56% of patients had a significant positive response, while 44% were nonresponders. This study indicates that response to lithium augmentation may be quite variable and a 3-week trial is necessary to assess full benefit.
AB - Eighty-four patients with major depression refractory to a controlled antidepressant trial had lithium added to their ongoing treatment. Objective symptom ratings showed highly significant improvement in the sample as a whole. At discharge or after 24 days, 31% of the patients showed a marked response, 25% a partial response, 39% no change, and 5% an adverse response. Thus, 56% of patients had a significant positive response, while 44% were nonresponders. This study indicates that response to lithium augmentation may be quite variable and a 3-week trial is necessary to assess full benefit.
UR - http://www.scopus.com/inward/record.url?scp=0023032984&partnerID=8YFLogxK
U2 - 10.1176/ajp.143.11.1387
DO - 10.1176/ajp.143.11.1387
M3 - Article
C2 - 3096155
AN - SCOPUS:0023032984
SN - 0002-953X
VL - 143
SP - 1387
EP - 1392
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 11
ER -