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Valproic acid and pregnancy: Not tried other medications

  • Nigar Dargah-Zada
  • , Cynthia L. Harden
  • , Anne Sabers
  • , M. Sazgar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

A 24-year-old woman was diagnosed with juvenile myoclonic epilepsy (JME) since age 14 and managed by her pediatric neurologist. She has been successfully treated and remained seizure free on valproic acid 500 mg twice daily for several years. She has never been tried on any other seizure medications. She has a full-time job as a real estate agent and drives clients around the city. She reports no side effects on valproic acid. She has been transferred to your care as an adult neurologist. She got married 2 years ago and is planning to become pregnant and start a family in the next year or two. How would you counsel her regarding the risks for teratogenicity of her seizure medication and what treatment changes would you make, if any?.

Original languageEnglish
Title of host publicationControversies in Caring for Women with Epilepsy
Subtitle of host publicationSorting Through the Evidence
PublisherSpringer International Publishing
Pages73-79
Number of pages7
ISBN (Electronic)9783319291703
ISBN (Print)9783319291680
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes

Keywords

  • Autism
  • Congenital malformation
  • Juvenile myoclonic epilepsy
  • Lamotrigine
  • Levetiracetam
  • Neurodevelopment
  • Pre-pregnancy counselling
  • Pregnancy
  • Teratogenesis
  • Valproate
  • Valproic acid

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