Valproic acid and pregnancy: Failed other medications

Fábio A. Nascimento; Lara V. Marcuse; Danielle M. Andrade; C. L. Harden

doi:10.1007/978-3-319-29170-3_8

Valproic acid and pregnancy: Failed other medications

Fábio A. Nascimento, Lara V. Marcuse, Danielle M. Andrade, C. L. Harden

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

A 25-year-old woman was diagnosed with Juvenile Myoclonic Epilepsy (JME) since age 13. She was tried on lamotrigine which resulted in full body rash. She has failed other medications including topiramate, zonisamide, and levetiracetam due to lack of efficacy for controlling her seizures. She has been managed with valproic acid in the past 5 years with no reported seizure recurrence. She would like to get pregnant in the next year or two. How would you counsel her and what treatment changes would you make, if any?.

Original language	English
Title of host publication	Controversies in Caring for Women with Epilepsy
Subtitle of host publication	Sorting Through the Evidence
Publisher	Springer International Publishing
Pages	63-71
Number of pages	9
ISBN (Electronic)	9783319291703
ISBN (Print)	9783319291680
DOIs	https://doi.org/10.1007/978-3-319-29170-3_8
State	Published - 1 Jan 2016
Externally published	Yes

Keywords

Antiepileptic drugs
Autism spectrum disorders
Cognitive effects
Dose relationships
Dose-dependent
EURAP
Epilepsy
Fetal malformations
Fetus
Malformations
NEAD study group
Neurodevelopment
North American pregnancy registry
Pregnancy
Seizure
Teratogenic
Valproate
Valproic acid

Access to Document

10.1007/978-3-319-29170-3_8

Cite this

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title = "Valproic acid and pregnancy: Failed other medications",

abstract = "A 25-year-old woman was diagnosed with Juvenile Myoclonic Epilepsy (JME) since age 13. She was tried on lamotrigine which resulted in full body rash. She has failed other medications including topiramate, zonisamide, and levetiracetam due to lack of efficacy for controlling her seizures. She has been managed with valproic acid in the past 5 years with no reported seizure recurrence. She would like to get pregnant in the next year or two. How would you counsel her and what treatment changes would you make, if any?.",

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author = "Nascimento, {F{\'a}bio A.} and Marcuse, {Lara V.} and Andrade, {Danielle M.} and Harden, {C. L.}",

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doi = "10.1007/978-3-319-29170-3_8",

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AU - Nascimento, Fábio A.

AU - Marcuse, Lara V.

AU - Andrade, Danielle M.

AU - Harden, C. L.

N1 - Publisher Copyright: © Springer International Publishing Switzerland 2016.

PY - 2016/1/1

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KW - Autism spectrum disorders

KW - Cognitive effects

KW - Dose relationships

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KW - Fetal malformations

KW - Fetus

KW - Malformations

KW - NEAD study group

KW - Neurodevelopment

KW - North American pregnancy registry

KW - Pregnancy

KW - Seizure

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KW - Valproic acid

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SP - 63

EP - 71

BT - Controversies in Caring for Women with Epilepsy

PB - Springer International Publishing

ER -

Valproic acid and pregnancy: Failed other medications

Abstract

Keywords

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