Valproic acid and pregnancy: Failed other medications

Fábio A. Nascimento, Lara V. Marcuse, Danielle M. Andrade, C. L. Harden

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


A 25-year-old woman was diagnosed with Juvenile Myoclonic Epilepsy (JME) since age 13. She was tried on lamotrigine which resulted in full body rash. She has failed other medications including topiramate, zonisamide, and levetiracetam due to lack of efficacy for controlling her seizures. She has been managed with valproic acid in the past 5 years with no reported seizure recurrence. She would like to get pregnant in the next year or two. How would you counsel her and what treatment changes would you make, if any?.

Original languageEnglish
Title of host publicationControversies in Caring for Women with Epilepsy
Subtitle of host publicationSorting Through the Evidence
PublisherSpringer International Publishing
Number of pages9
ISBN (Electronic)9783319291703
ISBN (Print)9783319291680
StatePublished - 1 Jan 2016
Externally publishedYes


  • Antiepileptic drugs
  • Autism spectrum disorders
  • Cognitive effects
  • Dose relationships
  • Dose-dependent
  • Epilepsy
  • Fetal malformations
  • Fetus
  • Malformations
  • NEAD study group
  • Neurodevelopment
  • North American pregnancy registry
  • Pregnancy
  • Seizure
  • Teratogenic
  • Valproate
  • Valproic acid


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