TY - JOUR
T1 - Validating GWAS-Identified Risk Loci for Alzheimer’s Disease in Han Chinese Populations
AU - Wang, Hui Zhen
AU - Bi, Rui
AU - Hu, Qiu Xiang
AU - Xiang, Qun
AU - Zhang, Chen
AU - Zhang, Deng Feng
AU - Zhang, Wen
AU - Ma, Xiaohong
AU - Guo, Wanjun
AU - Deng, Wei
AU - Zhao, Liansheng
AU - Ni, Peiyan
AU - Li, Mingli
AU - Fang, Yiru
AU - Li, Tao
AU - Yao, Yong Gang
N1 - Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - In recent years, genome-wide association studies (GWASs) have identified many novel susceptible genes/loci for Alzheimer’s disease (AD). However, most of these studies were conducted in European and populations of European origin, and limited studies have been performed in Han Chinese. In this study, we genotyped 14 single-nucleotide polymorphisms (SNPs) in eight GWAS-reported AD risk genes in 1509 individuals comprising two independent Han Chinese case-control cohorts. Four SNPs (rs11234495, rs592297, rs676733, and rs3851179) in the PICALM gene were significantly associated with late-onset (LO)-AD in populations from Southwest China, whereas SNPs rs744373 (BIN1), rs9331942 (CLU), and rs670139 (MS4A4E) were linked to LO-AD in populations from East China. In the combined Han Chinese population, positive associations were observed between PICALM, CLU, MS4A4E genes, and LO-AD. The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations. Our study verified the association between PICALM, BIN1, CLU, and MS4A4E variants and AD susceptibility in Han Chinese populations. We also discerned some regional differences concerning AD susceptibility SNPs.
AB - In recent years, genome-wide association studies (GWASs) have identified many novel susceptible genes/loci for Alzheimer’s disease (AD). However, most of these studies were conducted in European and populations of European origin, and limited studies have been performed in Han Chinese. In this study, we genotyped 14 single-nucleotide polymorphisms (SNPs) in eight GWAS-reported AD risk genes in 1509 individuals comprising two independent Han Chinese case-control cohorts. Four SNPs (rs11234495, rs592297, rs676733, and rs3851179) in the PICALM gene were significantly associated with late-onset (LO)-AD in populations from Southwest China, whereas SNPs rs744373 (BIN1), rs9331942 (CLU), and rs670139 (MS4A4E) were linked to LO-AD in populations from East China. In the combined Han Chinese population, positive associations were observed between PICALM, CLU, MS4A4E genes, and LO-AD. The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations. Our study verified the association between PICALM, BIN1, CLU, and MS4A4E variants and AD susceptibility in Han Chinese populations. We also discerned some regional differences concerning AD susceptibility SNPs.
KW - Alzheimer’s disease
KW - GWAS
KW - Han Chinese
KW - Variants
UR - https://www.scopus.com/pages/publications/84953363265
U2 - 10.1007/s12035-014-9015-z
DO - 10.1007/s12035-014-9015-z
M3 - Article
C2 - 25452228
AN - SCOPUS:84953363265
SN - 0893-7648
VL - 53
SP - 379
EP - 390
JO - Molecular Neurobiology
JF - Molecular Neurobiology
IS - 1
ER -