Vaccination and allergy: EAACI position paper, practical aspects

Lennart Nilsson, Knut Brockow, Johan Alm, Victoria Cardona, Jean Christoph Caubet, Eva Gomes, Maria C. Jenmalm, Susanne Lau, Eva Netterlid, Jürgen Schwarze, Aziz Sheikh, Jann Storsaeter, Chrysanthi Skevaki, Ingrid Terreehorst, Giovanna Zanoni

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


Immunization is highly effective in preventing infectious diseases and therefore an indispensable public health measure. Allergic patients deserve access to the same publicly recommended immunizations as non-allergic patients unless risks associated with vaccination outweigh the gains. Whereas the number of reported possible allergic reactions to vaccines is high, confirmed vaccine-triggered allergic reactions are rare. Anaphylaxis following vaccination is rare, affecting <1/100 000, but can occur in any patient. Some patient groups, notably those with a previous allergic reaction to a vaccine or its components, are at heightened risk of allergic reaction and require special precautions. Allergic reactions, however, may occur in patients without known risk factors and cannot be predicted by currently available tools. Unwarranted fear and uncertainty can result in incomplete vaccination coverage for children and adults with or without allergy. In addition to concerns about an allergic reaction to the vaccine itself, there is fear that routine childhood immunization may promote the development of allergic sensitization and disease. Thus, although there is no evidence that routine childhood immunization increases the risk of allergy development, such risks need to be discussed.

Original languageEnglish
Pages (from-to)628-640
Number of pages13
JournalPediatric Allergy and Immunology
Issue number7
StatePublished - Nov 2017
Externally publishedYes


  • adjuvant
  • adverse event
  • allergy
  • anaphylaxis
  • vaccination


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