Utilizing Upadacitinib for the Management of Hailey-Hailey Disease

Hayden Y.K. Fung, William C. Lau, Mark G. Lebwohl

Research output: Contribution to journalArticlepeer-review

Abstract

Hailey-Hailey Disease is a rare disease associated with mutation of the ATP2C1 gene characterized by skin blistering and erosion. Here, we report a case of a patient with Hailey-Hailey disease who significantly improved after treatment with upadacitinib. A 55-year-old male with biopsy-confirmed Hailey-Hailey disease presented with a 20-year history of ill-defined, brightly erythematous, painful patches initially on the neck and subsequently involving the penile shaft. Following treatment with 30 mg of upadacitinib, the patient’s neck ulcer gradually reepithelized. This case adds to the growing body of literature supporting the use of Janus kinase inhibitors as a therapeutic modality for this condition.

Original languageEnglish
Pages (from-to)2021-2024
Number of pages4
JournalSKIN: Journal of Cutaneous Medicine
Volume8
Issue number6
DOIs
StatePublished - Nov 2024

Keywords

  • hailey hailey disease
  • janus kinase inhibitors
  • upadacitinib

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