Utility of optical coherence tomography in acute coronary syndromes

Keyvan Karimi Galougahi, Ali Dakroub, Karen Chau, Rony Mathew, Ajit Mullasari, Balbir Singh, Gunasekaran Sengottuvelu, Akiko Maehara, Gary Mintz, Allen Jeremias, Evan Shlofmitz, Nick E.J. West, Richard Shlofmitz, Ziad A. Ali

Research output: Contribution to journalReview articlepeer-review


Studies utilizing intravascular imaging have replicated the findings of histopathological studies, identifying the most common substrates for acute coronary syndromes (ACS) as plaque rupture, erosion, and calcified nodule, with spontaneous coronary artery dissection, coronary artery spasm, and coronary embolism constituting the less common etiologies. The purpose of this review is to summarize the data from clinical studies that have used high-resolution intravascular optical coherence tomography (OCT) to assess culprit plaque morphology in ACS. In addition, we discuss the utility of intravascular OCT for effective treatment of patients presenting with ACS, including the possibility of culprit lesion-based treatment by percutaneous coronary intervention.

Original languageEnglish
Pages (from-to)46-55
Number of pages10
JournalCatheterization and Cardiovascular Interventions
Issue number1
StatePublished - 1 Jul 2023
Externally publishedYes


  • acute coronary syndromes
  • calcified nodule
  • optical coherence tomography
  • percutaneous coronary intervention
  • plaque erosion
  • plaque rupture


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