Utility of intravenous immune globulin in kidney transplantation: Efficacy, safety, and cost implications

Stanley Jordan, Charlotte Cunningham-Rundles, Robert McEwanc

Research output: Contribution to journalShort surveypeer-review

127 Scopus citations

Abstract

Intravenous immunoglobulin preparations (IVIG) are known to be effective in the treatment of various autoimmune and inflammatory disorders into their immunomodulatory, immunoregulatory, and anti-inflammatory properties. Recently, IVIG has been utilized in the management of highly sensitized patients awaiting renal transplantation. The mechanisms of suppression of panel reactive antibodies (PRA) in patients awaiting transplantation are currently under investigation and appear to be related to anti-idiotypic antibodies present in IVIG preparations. In this review, the various immunomodulatory mechanisms attributable to IVIG and their efficacy in reducing PRAs will be described. In addition, the use of IVIG in solid organ transplant recipients will be reviewed. The adverse events, safety considerations, and economic impact of IVIG protocols for patients awaiting solid organ transplantation will be discussed.

Original languageEnglish
Pages (from-to)653-664
Number of pages12
JournalAmerican Journal of Transplantation
Volume3
Issue number6
DOIs
StatePublished - Jun 2003

Keywords

  • IVIG
  • Kidney transplantation
  • Panel reactive antibodies

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