TY - JOUR
T1 - Utility of intravenous immune globulin in kidney transplantation
T2 - Efficacy, safety, and cost implications
AU - Jordan, Stanley
AU - Cunningham-Rundles, Charlotte
AU - McEwanc, Robert
PY - 2003/6
Y1 - 2003/6
N2 - Intravenous immunoglobulin preparations (IVIG) are known to be effective in the treatment of various autoimmune and inflammatory disorders into their immunomodulatory, immunoregulatory, and anti-inflammatory properties. Recently, IVIG has been utilized in the management of highly sensitized patients awaiting renal transplantation. The mechanisms of suppression of panel reactive antibodies (PRA) in patients awaiting transplantation are currently under investigation and appear to be related to anti-idiotypic antibodies present in IVIG preparations. In this review, the various immunomodulatory mechanisms attributable to IVIG and their efficacy in reducing PRAs will be described. In addition, the use of IVIG in solid organ transplant recipients will be reviewed. The adverse events, safety considerations, and economic impact of IVIG protocols for patients awaiting solid organ transplantation will be discussed.
AB - Intravenous immunoglobulin preparations (IVIG) are known to be effective in the treatment of various autoimmune and inflammatory disorders into their immunomodulatory, immunoregulatory, and anti-inflammatory properties. Recently, IVIG has been utilized in the management of highly sensitized patients awaiting renal transplantation. The mechanisms of suppression of panel reactive antibodies (PRA) in patients awaiting transplantation are currently under investigation and appear to be related to anti-idiotypic antibodies present in IVIG preparations. In this review, the various immunomodulatory mechanisms attributable to IVIG and their efficacy in reducing PRAs will be described. In addition, the use of IVIG in solid organ transplant recipients will be reviewed. The adverse events, safety considerations, and economic impact of IVIG protocols for patients awaiting solid organ transplantation will be discussed.
KW - IVIG
KW - Kidney transplantation
KW - Panel reactive antibodies
UR - http://www.scopus.com/inward/record.url?scp=0037869387&partnerID=8YFLogxK
U2 - 10.1034/j.1600-6143.2003.00121.x
DO - 10.1034/j.1600-6143.2003.00121.x
M3 - Short survey
C2 - 12780556
AN - SCOPUS:0037869387
SN - 1600-6135
VL - 3
SP - 653
EP - 664
JO - American Journal of Transplantation
JF - American Journal of Transplantation
IS - 6
ER -