Utility of bone marrow aspirate and biopsy in staging of patients with T-cell lymphoma in the PET-Era–tissue remains the issue

Suchitra Sundaram, Mazen Jizzini, Dominick Lamonica, Kristopher Attwood, Matthew Gravina, Francisco Hernandez-Ilizaliturri, Pallawi Torka

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The role of 18F-fluoro-2-deoxy-D-glucose positron emission tomography combined with computerized tomography (PET-CT) in evaluation of bone marrow involvement (BMI) in patients with T-cell lymphoma (TCL) is poorly understood. We investigated whether PET-CT could replace bone marrow aspiration and biopsy (BMAB) in TCL. Sixty patients with newly diagnosed TCL who underwent both diagnostic PET-CT and BMAB were identified. BMI was tissue-confirmed in 15 (25%) cases, however only 8 of these 15 showed BMI on PET-CT (sensitivity of 53.3%, specificity of 100%). BMI by BMAB was associated with lower progression-free survival (PFS) (p = 0.038) and overall survival (OS) (p = 0.003) while PET-CT BMI was associated only with OS (p = 0.02). BMI detected by BMAB in the setting of a negative PET-CT had similar inferior prognosis as BMI identified on PET-CT. Thus, PET-CT in TCL misses BMI in almost half of the cases detected by BMAB and hence cannot substitute BMAB in evaluation of TCL.

Original languageEnglish
Pages (from-to)3226-3233
Number of pages8
JournalLeukemia and Lymphoma
Volume61
Issue number13
DOIs
StatePublished - 2020
Externally publishedYes

Keywords

  • PET scan
  • Positron emission tomography
  • T cell lymphoma
  • bone marrow biopsy
  • bone marrow evaluation
  • bone marrow involvement

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