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USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment
Zhen Wang
, Chao Qian
, Yan Xiong
, Dingpeng Zhang
, Hiroyuki Inuzuka
, Yue Zhong
, Ling Xie
, Xian Chen
,
Jian Jin
, Wenyi Wei
Graduate School of Biomedical Sciences
Icahn School of Medicine at Mount Sinai
Cancer Clinical Investigation
Friedman Brain Institute
Oncological Sciences
Pharmacological Sciences
Mount Sinai Tisch Cancer Center
Research output
:
Contribution to journal
›
Article
›
peer-review
12
Scopus citations
Overview
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Keyphrases
Anticancer Therapeutics
10%
Antiproliferative Activity
10%
Cancer Cell Proliferation
10%
Cancer Metabolism
10%
Cancer Treatment
100%
CGAS-STING
10%
Chimera
100%
Cyclic GMP-AMP Synthase (cGAS)
20%
Deubiquitinase
100%
First-in-class
10%
Hijacking
10%
Metabolic Pathway
10%
Mutant Protein
10%
Non-covalent
10%
OTUB1
20%
Protein Stabilization
10%
Strategic pivot
10%
Target Molecule
10%
Therapeutic Approaches
10%
Tumor Suppressor
20%
Ubiquitin-specific Protease 7 (USP7)
20%
USP28
100%
Biochemistry, Genetics and Molecular Biology
Anticancer
33%
Antiproliferative Activity
33%
Cancer Cell
33%
Cell Proliferation
33%
cGAS-STING
33%
Metabolic Pathway
33%
Mutant Protein
33%
Peroxisome Proliferator-Activated Receptor
100%
Tumor Suppressor Protein
66%
USP7
66%
Pharmacology, Toxicology and Pharmaceutical Science
Deubiquitinase
100%
Malignant Neoplasm
100%
Mutant Protein
10%
Peroxisome Proliferator Activated Receptor
30%
Tumor Suppressor Protein
20%