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USP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment
Zhen Wang
, Chao Qian
, Yan Xiong
, Dingpeng Zhang
, Hiroyuki Inuzuka
, Yue Zhong
, Ling Xie
, Xian Chen
,
Jian Jin
, Wenyi Wei
Graduate School of Biomedical Sciences
Icahn School of Medicine at Mount Sinai
Cancer Clinical Investigation
Friedman Brain Institute
Oncological Sciences
Pharmacological Sciences
Mount Sinai Tisch Cancer Center
Research output
:
Contribution to journal
›
Article
›
peer-review
9
Scopus citations
Overview
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Keyphrases
Cancer Treatment
100%
Chimera
100%
Deubiquitinase
100%
USP28
100%
Tumor Suppressor
20%
Cyclic GMP-AMP Synthase (cGAS)
20%
Ubiquitin-specific Protease 7 (USP7)
20%
OTUB1
20%
Cancer Cell Proliferation
10%
Target Molecule
10%
Antiproliferative Activity
10%
First-in-class
10%
Therapeutic Approaches
10%
Metabolic Pathway
10%
Mutant Protein
10%
Non-covalent
10%
Hijacking
10%
Anticancer Therapeutics
10%
Cancer Metabolism
10%
Protein Stabilization
10%
CGAS-STING
10%
Strategic pivot
10%
Biochemistry, Genetics and Molecular Biology
Peroxisome Proliferator-Activated Receptor
100%
Tumor Suppressor Protein
66%
USP7
66%
Cancer Cell
33%
Cell Proliferation
33%
Metabolic Pathway
33%
Anticancer
33%
Mutant Protein
33%
Antiproliferative Activity
33%
cGAS-STING
33%
Pharmacology, Toxicology and Pharmaceutical Science
Malignant Neoplasm
100%
Deubiquitinase
100%
Peroxisome Proliferator Activated Receptor
30%
Tumor Suppressor Protein
20%
Mutant Protein
10%