Using Opioid Receptors to Expand the Chemogenetic and Optogenetic Toolbox

Diane M. Damez-Werno; Paul J. Kenny

doi:10.1016/j.neuron.2015.05.014

Using Opioid Receptors to Expand the Chemogenetic and Optogenetic Toolbox

Diane M. Damez-Werno, Paul J. Kenny

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy etal. (2015) describe a new "DREADD" chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-availableDREADDs. Siuda etal. (2015) report the development of "opto-MOR," a light-activatable μ opioidreceptor (MOR) chimera that can be used to better understand the complexities of MOR signaling.

Original language	English
Pages (from-to)	853-855
Number of pages	3
Journal	Neuron
Volume	86
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2015.05.014
State	Published - 20 May 2015

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AB - In this issue of Neuron, innovative new modifications to opioid receptors are used to expand the tools available to modulate neuronal activity. Vardy etal. (2015) describe a new "DREADD" chemogenetic tool based on the inhibitory κ opioid receptor (KORD) that can be used in conjunction with already-availableDREADDs. Siuda etal. (2015) report the development of "opto-MOR," a light-activatable μ opioidreceptor (MOR) chimera that can be used to better understand the complexities of MOR signaling.

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Using Opioid Receptors to Expand the Chemogenetic and Optogenetic Toolbox

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