TY - JOUR
T1 - Using nontraditional risk factors in coronary heart disease risk assessment
T2 - U.S. preventive services task force recommendation statement
AU - Calonge, Ned
AU - Petitti, Diana B.
AU - DeWitt, Thomas G.
AU - Gregory, Kimberly D.
AU - Harris, Russell
AU - Isham, George
AU - LeFevre, Michael L.
AU - Loveland-Cherry, Carol
AU - Marion, Lucy N.
AU - Moyer, Virginia A.
AU - Ockene, Judith K.
AU - Sawaya, George F.
AU - Siu, Albert L.
AU - Teutsch, Steven M.
AU - Yawn, Barbara P.
PY - 2009/10/6
Y1 - 2009/10/6
N2 - Description: New recommendation from the U.S. Preventive Services Task Force (USPSTF) on the use of nontraditional, or novel, risk factors in assessing the coronary heart disease (CHD) risk of asymptomatic persons. Methods: Systematic reviews were conducted of literature since 1996 on 9 proposed nontraditional markers of CHD risk: highsensitivity C-reactive protein, ankle-brachial index, leukocyte count, fasting blood glucose, periodontal disease, carotid intima-media thickness, coronary artery calcification score on electron-beam computed tomography, homocysteine, and lipoprotein(a). The reviews followed a hierarchical approach aimed at determining which factors could practically and definitively reassign persons assessed as intermediate-risk according to their Framingham score to either a high-risk or low-risk strata, and thereby improve outcomes by means of aggressive risk-factor modification in those newly assigned to the high-risk stratum. Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of using the nontraditional risk factors studied to screen asymptomatic men and women with no history of CHD to prevent CHD events. (I statement).
AB - Description: New recommendation from the U.S. Preventive Services Task Force (USPSTF) on the use of nontraditional, or novel, risk factors in assessing the coronary heart disease (CHD) risk of asymptomatic persons. Methods: Systematic reviews were conducted of literature since 1996 on 9 proposed nontraditional markers of CHD risk: highsensitivity C-reactive protein, ankle-brachial index, leukocyte count, fasting blood glucose, periodontal disease, carotid intima-media thickness, coronary artery calcification score on electron-beam computed tomography, homocysteine, and lipoprotein(a). The reviews followed a hierarchical approach aimed at determining which factors could practically and definitively reassign persons assessed as intermediate-risk according to their Framingham score to either a high-risk or low-risk strata, and thereby improve outcomes by means of aggressive risk-factor modification in those newly assigned to the high-risk stratum. Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of using the nontraditional risk factors studied to screen asymptomatic men and women with no history of CHD to prevent CHD events. (I statement).
UR - http://www.scopus.com/inward/record.url?scp=70349976327&partnerID=8YFLogxK
U2 - 10.7326/0003-4819-151-7-200910060-00008
DO - 10.7326/0003-4819-151-7-200910060-00008
M3 - Review article
C2 - 19805770
AN - SCOPUS:70349976327
SN - 0003-4819
VL - 151
SP - 474
EP - 482
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 7
ER -