TY - JOUR
T1 - Using a hydroquinone/tretinoin-based skin care system before and after electrodesiccation and curettage of superficial truncal basal cell carcinoma
AU - Pariser, David
AU - Spencer, James
AU - Berman, Brian
AU - Bruce, Suzanne
AU - Parr, Lisa
AU - Gross, Kenneth
PY - 2009/5
Y1 - 2009/5
N2 - Objective: To evaluate the efficacy and tolerability of using a 4% hydroquinone/0.05% tretinoin skin care system compared with standard treatment of cleanser plus healing ointment to enhance aesthetic outcomes resulting from electrodesiccation and curettage treatment for superficial truncal basal cell carcinomas. Design: Multicenter, investigator-masked, randomized, parallel-group study. Patients received either the hydroquinone/tretinoin system or the standard treatment twice daily for three weeks before and after electrodesiccation and curettage (post-electrodesiccation and curettage, lesions received standard treatment until reepithelialization was greater than or equal to 75 percent; assigned treatment regimens then resumed). Setting: Patients attending academic, institutional, and private dermatology clinics. Participants: 51 patients with 1 to 3 superficial truncal basal cell carcinomas. Measurements: The primary efficacy outcome was the incidence of treatment success for scar cosmesis, defined as a global assessment of excellent or good wound appearance (on a scale of excellent, good, fair, and poor), as evaluated by the investigators. After the end of the study, seven expert masked graders (dermatologists or plastic surgeons) reviewed the photographs from all of the lesions and also evaluated global assessment. Results: The incidence of treatment success in the hydroquinone/tretinoin and standard treatment groups was 72 percent versus 63 percent according to the masked investigators and 45 to 68 percent versus 20 to 44 percent, respectively, according to the seven expert masked graders. All the expert graders reported a higher incidence of treatment success with the hydroquinone/ tretinoin system than with standard treatment and this difference was statistically significant for five of the seven graders. Conclusion: The adjunctive use of the hydroquinone/tretinoin skin care system may offer enhanced aesthetic results postelectrodesiccation and curettage compared with standard treatment.
AB - Objective: To evaluate the efficacy and tolerability of using a 4% hydroquinone/0.05% tretinoin skin care system compared with standard treatment of cleanser plus healing ointment to enhance aesthetic outcomes resulting from electrodesiccation and curettage treatment for superficial truncal basal cell carcinomas. Design: Multicenter, investigator-masked, randomized, parallel-group study. Patients received either the hydroquinone/tretinoin system or the standard treatment twice daily for three weeks before and after electrodesiccation and curettage (post-electrodesiccation and curettage, lesions received standard treatment until reepithelialization was greater than or equal to 75 percent; assigned treatment regimens then resumed). Setting: Patients attending academic, institutional, and private dermatology clinics. Participants: 51 patients with 1 to 3 superficial truncal basal cell carcinomas. Measurements: The primary efficacy outcome was the incidence of treatment success for scar cosmesis, defined as a global assessment of excellent or good wound appearance (on a scale of excellent, good, fair, and poor), as evaluated by the investigators. After the end of the study, seven expert masked graders (dermatologists or plastic surgeons) reviewed the photographs from all of the lesions and also evaluated global assessment. Results: The incidence of treatment success in the hydroquinone/tretinoin and standard treatment groups was 72 percent versus 63 percent according to the masked investigators and 45 to 68 percent versus 20 to 44 percent, respectively, according to the seven expert masked graders. All the expert graders reported a higher incidence of treatment success with the hydroquinone/ tretinoin system than with standard treatment and this difference was statistically significant for five of the seven graders. Conclusion: The adjunctive use of the hydroquinone/tretinoin skin care system may offer enhanced aesthetic results postelectrodesiccation and curettage compared with standard treatment.
UR - http://www.scopus.com/inward/record.url?scp=77954253619&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77954253619
SN - 1941-2789
VL - 2
SP - 38
EP - 43
JO - Journal of Clinical and Aesthetic Dermatology
JF - Journal of Clinical and Aesthetic Dermatology
IS - 5
ER -