TY - JOUR
T1 - Use of the aplysia feeding network to study repetition priming of an episodic behavior
AU - Cropper, Elizabeth C.
AU - Jing, Jian
AU - Perkins, Matthew H.
AU - Weiss, Klaudiusz R.
N1 - Publisher Copyright:
© 2017 the American Physiological Society.
PY - 2017/9/14
Y1 - 2017/9/14
N2 - Many central pattern generator (CPG)-mediated behaviors are episodic, meaning that they are not continuously ongoing; instead, there are pauses between bouts of activity. This raises an interesting possibility, that the neural networks that mediate these behaviors are not operating under “steady-state” conditions; i.e., there could be dynamic changes in motor activity as it stops and starts. Research in the feeding system of the mollusk Aplysia californica has demonstrated that this can be the case. After a pause, initial food grasping responses are relatively weak. With repetition, however, responses strengthen. In this review we describe experiments that have characterized cellular/molecular mechanisms that produce these changes in motor activity. In particular, we focus on cumulative effects of modulatory neuropeptides. Furthermore, we relate Aplysia research to work in other systems and species, and develop a hypothesis that postulates that changes in response magnitude are a reflection of an efficient feeding strategy.
AB - Many central pattern generator (CPG)-mediated behaviors are episodic, meaning that they are not continuously ongoing; instead, there are pauses between bouts of activity. This raises an interesting possibility, that the neural networks that mediate these behaviors are not operating under “steady-state” conditions; i.e., there could be dynamic changes in motor activity as it stops and starts. Research in the feeding system of the mollusk Aplysia californica has demonstrated that this can be the case. After a pause, initial food grasping responses are relatively weak. With repetition, however, responses strengthen. In this review we describe experiments that have characterized cellular/molecular mechanisms that produce these changes in motor activity. In particular, we focus on cumulative effects of modulatory neuropeptides. Furthermore, we relate Aplysia research to work in other systems and species, and develop a hypothesis that postulates that changes in response magnitude are a reflection of an efficient feeding strategy.
KW - Feeding microstructure
KW - Invertebrate
KW - Neuromodulation
KW - Neuropeptides
UR - http://www.scopus.com/inward/record.url?scp=85029652250&partnerID=8YFLogxK
U2 - 10.1152/jn.00373.2017
DO - 10.1152/jn.00373.2017
M3 - Review article
C2 - 28679841
AN - SCOPUS:85029652250
SN - 0022-3077
VL - 118
SP - 1861
EP - 1870
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
IS - 3
M1 - 1014
ER -