Use of mouse models to study the mechanisms and consequences of RBC clearance

E. A. Hod; S. A. Arinsburg; R. O. Francis; J. E. Hendrickson; J. C. Zimring; S. L. Spitalnik

doi:10.1111/j.1423-0410.2010.01327.x

Use of mouse models to study the mechanisms and consequences of RBC clearance

E. A. Hod
, S. A. Arinsburg
, R. O. Francis
, J. E. Hendrickson
, J. C. Zimring
, S. L. Spitalnik

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.

Original language	English
Pages (from-to)	99-111
Number of pages	13
Journal	Vox Sanguinis
Volume	99
Issue number	2
DOIs	https://doi.org/10.1111/j.1423-0410.2010.01327.x
State	Published - Aug 2010
Externally published	Yes

Keywords

Immuno-haematology
RBC antigens and antibodies
Transfusion reactions

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10.1111/j.1423-0410.2010.01327.x

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title = "Use of mouse models to study the mechanisms and consequences of RBC clearance",

abstract = "Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.",

keywords = "Immuno-haematology, RBC antigens and antibodies, Transfusion reactions",

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AU - Hod, E. A.

AU - Arinsburg, S. A.

AU - Francis, R. O.

AU - Hendrickson, J. E.

AU - Zimring, J. C.

AU - Spitalnik, S. L.

PY - 2010/8

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N2 - Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.

AB - Mice provide tractable animal models for studying the pathophysiology of various human disorders. This review discusses the use of mouse models for understanding red-blood-cell (RBC) clearance. These models provide important insights into the pathophysiology of various clinically relevant entities, such as autoimmune haemolytic anaemia, haemolytic transfusion reactions, other complications of RBC transfusions and immunomodulation by Rh immune globulin therapy. Mouse models of both antibody- and non-antibody-mediated RBC clearance are reviewed. Approaches for exploring unanswered questions in transfusion medicine using these models are also discussed.

KW - Immuno-haematology

KW - RBC antigens and antibodies

KW - Transfusion reactions

UR - https://www.scopus.com/pages/publications/77954750726

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JO - Vox Sanguinis

JF - Vox Sanguinis

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ER -

Use of mouse models to study the mechanisms and consequences of RBC clearance

Abstract

Keywords

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