Use of Intraoperative Fluorophores

Alexander J. Schupper, Constantinos Hadjipanayis

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Fluorescence-guided surgery provides surgeons with improved visualization of tumor tissue in the operating room to allow for maximal safe resection of brain tumors. Multiple fluorescent agents have been studied for fluorescence-guided surgery. Both nontargeted and targeted fluorescent agents are currently being used for glioblastoma multiforme visualization and resection. Fluorescence detection in the visible light or near infrared spectrum is possible. Visualization device advancements have permitted greater detection of fluorescence down to the cellular level, which may provide even greater ability for the neurosurgeon to resect tumors.

Original languageEnglish
Pages (from-to)55-64
Number of pages10
JournalNeurosurgery Clinics of North America
Issue number1
StatePublished - Jan 2021
Externally publishedYes


  • 5-ALA
  • Fluorescein sodium
  • Fluorescence-guided surgery
  • Fluorophores
  • GBM
  • Glioblastoma
  • ICG
  • Targeted fluorophores


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