TY - JOUR
T1 - Use of an IgA-depleted intravenous immunoglobulin in a patient with an anti-IgA antibody
AU - Cunningham-Rundles, C.
AU - Wong, S.
AU - Bjorkander, J.
AU - Hanson, L. A.
N1 - Funding Information:
This work was supported in part by grants from US Public Health Service. Al-15809. CA-19267. CA-29502 and the American Cancer Society IM-245. the Zelda Radow Weintraub Cancer Fund. and the Beneficial Corporation. The authors thank Dr. Sudhir Gupta for referral of the patient. Mrs. Susan Gluckman and Mrs. Robin Tauer for nursing assistance. Kabi Vitrum Inc. for supplying the intravenous y-globulin preparation, and Dr. Ravi Bhalla for determining the complement component tCH50 Clq. C3) and immune complex levels.
PY - 1986/2
Y1 - 1986/2
N2 - In this report we describe the use of an IgA-depleted preparation of intravenous γ-globulin in a patient with hypogammaglobulinemia and an anti-IgA antibody. An IgA containing intravenous γ-globulin had previously produced anaphylactoid reactions, immune complex formation, and complement activation. The patient has had no reactions to the IgA-depleted preparation after 18 months of treatment; immune complex formation and complement activation have not been demonstrated, and the titer of antibody to IgA has diminished.
AB - In this report we describe the use of an IgA-depleted preparation of intravenous γ-globulin in a patient with hypogammaglobulinemia and an anti-IgA antibody. An IgA containing intravenous γ-globulin had previously produced anaphylactoid reactions, immune complex formation, and complement activation. The patient has had no reactions to the IgA-depleted preparation after 18 months of treatment; immune complex formation and complement activation have not been demonstrated, and the titer of antibody to IgA has diminished.
UR - http://www.scopus.com/inward/record.url?scp=0022629303&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(86)90133-9
DO - 10.1016/0090-1229(86)90133-9
M3 - Article
C2 - 3079685
AN - SCOPUS:0022629303
SN - 0090-1229
VL - 38
SP - 141
EP - 149
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -