Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome

D. Tosun; A. L. Reiss; A. D. Lee; R. A. Dutton; K. M. Hayashi; U. Bellugi; A. M. Galaburda; J. R. Korenberg; D. L. Mills; A. W. Toga; P. M. Thompson

doi:10.1109/ISBI.2006.1625132

Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome

D. Tosun
, A. L. Reiss
, A. D. Lee
, R. A. Dutton
, K. M. Hayashi
, U. Bellugi
, A. M. Galaburda
, J. R. Korenberg
, D. L. Mills
, A. W. Toga
, P. M. Thompson

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

14 Scopus citations

Abstract

In this paper, we describe the use of three different shape measures - i.e., shape index, curvedness, and L₂ norm of mean curvature - to quantify cortical gyrification and complexity, thereby evaluating brain structural differences between individuals with Williams syndrome (WS) and healthy controls. Unlike traditional measures of gyrification, the proposed measures analyze the intrinsic geometry of the cortex in three-dimensional (3-D) space. We analyzed the local and global cortical folding patterns of 39 WS and 39 controls using these shape measures, showing increased gyrification in the cingulate, visual cortex, superior parietal lobule, and central sulcus regions (more pronounced in the left brain hemisphere), and increased cortical complexity in left temporal and left parietal lobes in WS. These findings agree with, and extend, previously published studies and may relate to the characteristic clinical and cognitive profiles of individuals with WS.

Original language	English
Title of host publication	2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publication	From Nano to Macro - Proceedings
Publisher	IEEE Computer Society
Pages	1172-1175
Number of pages	4
ISBN (Print)	0780395778, 9780780395770
DOIs	https://doi.org/10.1109/ISBI.2006.1625132
State	Published - 2006
Externally published	Yes
Event	3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2006 - Arlington, VA, United States Duration: 6 Apr 2006 → 9 Apr 2006

Publication series

Name	2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume	2006

Conference

Conference	3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2006
Country/Territory	United States
City	Arlington, VA
Period	6/04/06 → 9/04/06

Access to Document

10.1109/ISBI.2006.1625132

Cite this

Tosun, D., Reiss, A. L., Lee, A. D., Dutton, R. A., Hayashi, K. M., Bellugi, U., Galaburda, A. M., Korenberg, J. R., Mills, D. L., Toga, A. W., & Thompson, P. M. (2006). Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 1172-1175). Article 1625132 (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006). IEEE Computer Society. https://doi.org/10.1109/ISBI.2006.1625132

Tosun, D. ; Reiss, A. L. ; Lee, A. D. et al. / Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome. 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. IEEE Computer Society, 2006. pp. 1172-1175 (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings).

@inproceedings{978ba437193e40119bd00c945aa3d973,

title = "Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome",

abstract = "In this paper, we describe the use of three different shape measures - i.e., shape index, curvedness, and L2 norm of mean curvature - to quantify cortical gyrification and complexity, thereby evaluating brain structural differences between individuals with Williams syndrome (WS) and healthy controls. Unlike traditional measures of gyrification, the proposed measures analyze the intrinsic geometry of the cortex in three-dimensional (3-D) space. We analyzed the local and global cortical folding patterns of 39 WS and 39 controls using these shape measures, showing increased gyrification in the cingulate, visual cortex, superior parietal lobule, and central sulcus regions (more pronounced in the left brain hemisphere), and increased cortical complexity in left temporal and left parietal lobes in WS. These findings agree with, and extend, previously published studies and may relate to the characteristic clinical and cognitive profiles of individuals with WS.",

author = "D. Tosun and Reiss, \{A. L.\} and Lee, \{A. D.\} and Dutton, \{R. A.\} and Hayashi, \{K. M.\} and U. Bellugi and Galaburda, \{A. M.\} and Korenberg, \{J. R.\} and Mills, \{D. L.\} and Toga, \{A. W.\} and Thompson, \{P. M.\}",

year = "2006",

doi = "10.1109/ISBI.2006.1625132",

language = "English",

isbn = "0780395778",

series = "2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings",

publisher = "IEEE Computer Society",

pages = "1172--1175",

booktitle = "2006 3rd IEEE International Symposium on Biomedical Imaging",

address = "United States",

note = "3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2006 ; Conference date: 06-04-2006 Through 09-04-2006",

}

Tosun, D, Reiss, AL, Lee, AD, Dutton, RA, Hayashi, KM, Bellugi, U, Galaburda, AM, Korenberg, JR, Mills, DL, Toga, AW & Thompson, PM 2006, Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome. in 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings., 1625132, 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings, vol. 2006, IEEE Computer Society, pp. 1172-1175, 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2006, Arlington, VA, United States, 6/04/06. https://doi.org/10.1109/ISBI.2006.1625132

Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome. / Tosun, D.; Reiss, A. L.; Lee, A. D. et al.
2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. IEEE Computer Society, 2006. p. 1172-1175 1625132 (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Tosun, D.

AU - Reiss, A. L.

AU - Lee, A. D.

AU - Dutton, R. A.

AU - Hayashi, K. M.

AU - Bellugi, U.

AU - Galaburda, A. M.

AU - Korenberg, J. R.

AU - Mills, D. L.

AU - Toga, A. W.

AU - Thompson, P. M.

PY - 2006

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N2 - In this paper, we describe the use of three different shape measures - i.e., shape index, curvedness, and L2 norm of mean curvature - to quantify cortical gyrification and complexity, thereby evaluating brain structural differences between individuals with Williams syndrome (WS) and healthy controls. Unlike traditional measures of gyrification, the proposed measures analyze the intrinsic geometry of the cortex in three-dimensional (3-D) space. We analyzed the local and global cortical folding patterns of 39 WS and 39 controls using these shape measures, showing increased gyrification in the cingulate, visual cortex, superior parietal lobule, and central sulcus regions (more pronounced in the left brain hemisphere), and increased cortical complexity in left temporal and left parietal lobes in WS. These findings agree with, and extend, previously published studies and may relate to the characteristic clinical and cognitive profiles of individuals with WS.

AB - In this paper, we describe the use of three different shape measures - i.e., shape index, curvedness, and L2 norm of mean curvature - to quantify cortical gyrification and complexity, thereby evaluating brain structural differences between individuals with Williams syndrome (WS) and healthy controls. Unlike traditional measures of gyrification, the proposed measures analyze the intrinsic geometry of the cortex in three-dimensional (3-D) space. We analyzed the local and global cortical folding patterns of 39 WS and 39 controls using these shape measures, showing increased gyrification in the cingulate, visual cortex, superior parietal lobule, and central sulcus regions (more pronounced in the left brain hemisphere), and increased cortical complexity in left temporal and left parietal lobes in WS. These findings agree with, and extend, previously published studies and may relate to the characteristic clinical and cognitive profiles of individuals with WS.

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M3 - Conference contribution

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T3 - 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings

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BT - 2006 3rd IEEE International Symposium on Biomedical Imaging

PB - IEEE Computer Society

T2 - 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2006

Y2 - 6 April 2006 through 9 April 2006

ER -

Tosun D, Reiss AL, Lee AD, Dutton RA, Hayashi KM, Bellugi U et al. Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings. IEEE Computer Society. 2006. p. 1172-1175. 1625132. (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings). doi: 10.1109/ISBI.2006.1625132

Use of 3-D cortical morphometry for mapping increased cortical gyrification and complexity in Williams syndrome

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