URINE i-TXB2 IN RENAL ALLOGRAFT REJECTION

M. L. Foegh; M. Zmudka; C. Cooley; J. F. Winchester; G. B. Helfrich; P. W. Ramwell; G. E. Schreiner

doi:10.1016/S0140-6736(81)90772-8

URINE i-TXB₂ IN RENAL ALLOGRAFT REJECTION

M. L. Foegh
, M. Zmudka
, C. Cooley
, J. F. Winchester
, G. B. Helfrich
, P. W. Ramwell
, G. E. Schreiner

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

Immunoreactive thromboxane B₂ (i-TXB₂) was measured in daily urine samples from twelve patients after renal transplantation. In 21 of 30 rejection episodes, the increase in i-TXB₂ preceded both the increase in serum β₂-microglobulin (β₂-MG) and the clinical diagnosis of rejection. In 26 of 30 rejection episodes, the increase in urine i-TXB₂ preceded the increase in serum creatinine. The degree of change in i-TXB₂ is greater than that of either serum β₂-MG or creatinine. Urinary i-TXB₂ was very high in one patient with deep venous thrombosis, but it did not rise in patients with urinary tract infection, pneumonia, or acute tubular necrosis. Thus, urinary i-TXB₂ seems to be an early indicator of clinical renal allograft rejection.

Original language	English
Pages (from-to)	431-434
Number of pages	4
Journal	The Lancet
Volume	318
Issue number	8244
DOIs	https://doi.org/10.1016/S0140-6736(81)90772-8
State	Published - 29 Aug 1981
Externally published	Yes

Access to Document

10.1016/S0140-6736(81)90772-8

Cite this

@article{ad33f8f85e674dc1a973d3bed295fa05,

title = "URINE i-TXB2 IN RENAL ALLOGRAFT REJECTION",

abstract = "Immunoreactive thromboxane B2 (i-TXB2) was measured in daily urine samples from twelve patients after renal transplantation. In 21 of 30 rejection episodes, the increase in i-TXB2 preceded both the increase in serum β2-microglobulin (β2-MG) and the clinical diagnosis of rejection. In 26 of 30 rejection episodes, the increase in urine i-TXB2 preceded the increase in serum creatinine. The degree of change in i-TXB2 is greater than that of either serum β2-MG or creatinine. Urinary i-TXB2 was very high in one patient with deep venous thrombosis, but it did not rise in patients with urinary tract infection, pneumonia, or acute tubular necrosis. Thus, urinary i-TXB2 seems to be an early indicator of clinical renal allograft rejection.",

author = "Foegh, \{M. L.\} and M. Zmudka and C. Cooley and Winchester, \{J. F.\} and Helfrich, \{G. B.\} and Ramwell, \{P. W.\} and Schreiner, \{G. E.\}",

year = "1981",

month = aug,

day = "29",

doi = "10.1016/S0140-6736(81)90772-8",

language = "English",

volume = "318",

pages = "431--434",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier B.V.",

number = "8244",

}

TY - JOUR

T1 - URINE i-TXB2 IN RENAL ALLOGRAFT REJECTION

AU - Foegh, M. L.

AU - Zmudka, M.

AU - Cooley, C.

AU - Winchester, J. F.

AU - Helfrich, G. B.

AU - Ramwell, P. W.

AU - Schreiner, G. E.

PY - 1981/8/29

Y1 - 1981/8/29

N2 - Immunoreactive thromboxane B2 (i-TXB2) was measured in daily urine samples from twelve patients after renal transplantation. In 21 of 30 rejection episodes, the increase in i-TXB2 preceded both the increase in serum β2-microglobulin (β2-MG) and the clinical diagnosis of rejection. In 26 of 30 rejection episodes, the increase in urine i-TXB2 preceded the increase in serum creatinine. The degree of change in i-TXB2 is greater than that of either serum β2-MG or creatinine. Urinary i-TXB2 was very high in one patient with deep venous thrombosis, but it did not rise in patients with urinary tract infection, pneumonia, or acute tubular necrosis. Thus, urinary i-TXB2 seems to be an early indicator of clinical renal allograft rejection.

AB - Immunoreactive thromboxane B2 (i-TXB2) was measured in daily urine samples from twelve patients after renal transplantation. In 21 of 30 rejection episodes, the increase in i-TXB2 preceded both the increase in serum β2-microglobulin (β2-MG) and the clinical diagnosis of rejection. In 26 of 30 rejection episodes, the increase in urine i-TXB2 preceded the increase in serum creatinine. The degree of change in i-TXB2 is greater than that of either serum β2-MG or creatinine. Urinary i-TXB2 was very high in one patient with deep venous thrombosis, but it did not rise in patients with urinary tract infection, pneumonia, or acute tubular necrosis. Thus, urinary i-TXB2 seems to be an early indicator of clinical renal allograft rejection.

UR - https://www.scopus.com/pages/publications/0019390689

U2 - 10.1016/S0140-6736(81)90772-8

DO - 10.1016/S0140-6736(81)90772-8

M3 - Article

C2 - 6115199

AN - SCOPUS:0019390689

SN - 0140-6736

VL - 318

SP - 431

EP - 434

JO - The Lancet

JF - The Lancet

IS - 8244

ER -

URINE i-TXB2 IN RENAL ALLOGRAFT REJECTION

Abstract

Access to Document

Fingerprint

Cite this

URINE i-TXB₂ IN RENAL ALLOGRAFT REJECTION