Urinary prostaglandin e2 excretion in chronic renal disease

S. Suzuki, R. Shapiro, P. J. Mulrow, S. Y. Tan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


To ascertain whether renal prostaglandin E2 production is impaired in chronic renal disease we measured urinary prostaglandin E2 in 25 female renal patients, and in 38 female normal volunteers. Prostaglandin E2 averaged 337 ± 63 ng/24 hr in 25 female renal patients, which was significantly higher (P < 0.01) than values in normal female subjects (166 ± 17 ng/24 hr). None of the renal patients excreted less than 50 ng/24 hr, whereas normals when treated with indomethacin averaged 30 ± 10 ng/24 hr (n=8). There were no significant correlations between prostaglandin E2 and creatinine clearance, or urine volume. No difference in prostaglandin E2 was encountered between hypertensive and normotensive renal patients. Our results indicate that renal prostaglandin E2 production is increased rather than decreased in renal disease. The failure to demonstrate decreased urinary prostaglandin E2 excretion in renal hypertension sharply contrasts with the situation in essential hypertension.

Original languageEnglish
Pages (from-to)377-382
Number of pages6
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number5
StatePublished - May 1980
Externally publishedYes


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