TY - JOUR
T1 - Urinary NGAL marks cystic disease in HIV-associated nephropathy
AU - Paragas, Neal
AU - Nickolas, Thomas L.
AU - Wyatt, Christina
AU - Forster, Catherine S.
AU - Sise, Meghan
AU - Morgello, Susan
AU - Jagla, Bernd
AU - Buchen, Charles
AU - Stella, Peter
AU - Sanna-Cherchi, Simone
AU - Carnevali, Maria Luisa
AU - Mattei, Silvia
AU - Bovino, Achiropita
AU - Argentiero, Lucia
AU - Magnano, Andrea
AU - Devarajan, Prasad
AU - Schmidt-Ott, Kai M.
AU - Allegri, Landino
AU - Klotman, Paul
AU - D'Agati, Vivette
AU - Gharavi, Ali G.
AU - Barasch, Jonathan
PY - 2009/8
Y1 - 2009/8
N2 - Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potential to aid in the noninvasive diagnosis of HIVAN. We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVAN than in HIV-positive and HIV-negative patients with other forms of chronic kidney disease. In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments of the nephron. In contrast, urinary NGAL did not correlate with proteinuria in human or in mouse models. These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage.
AB - Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potential to aid in the noninvasive diagnosis of HIVAN. We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVAN than in HIV-positive and HIV-negative patients with other forms of chronic kidney disease. In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments of the nephron. In contrast, urinary NGAL did not correlate with proteinuria in human or in mouse models. These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage.
UR - http://www.scopus.com/inward/record.url?scp=68049117319&partnerID=8YFLogxK
U2 - 10.1681/ASN.2009010065
DO - 10.1681/ASN.2009010065
M3 - Article
C2 - 19628667
AN - SCOPUS:68049117319
SN - 1046-6673
VL - 20
SP - 1687
EP - 1692
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 8
ER -