Urinary NGAL marks cystic disease in HIV-associated nephropathy

Neal Paragas, Thomas L. Nickolas, Christina Wyatt, Catherine S. Forster, Meghan Sise, Susan Morgello, Bernd Jagla, Charles Buchen, Peter Stella, Simone Sanna-Cherchi, Maria Luisa Carnevali, Silvia Mattei, Achiropita Bovino, Lucia Argentiero, Andrea Magnano, Prasad Devarajan, Kai M. Schmidt-Ott, Landino Allegri, Paul Klotman, Vivette D'AgatiAli G. Gharavi, Jonathan Barasch

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potential to aid in the noninvasive diagnosis of HIVAN. We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVAN than in HIV-positive and HIV-negative patients with other forms of chronic kidney disease. In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments of the nephron. In contrast, urinary NGAL did not correlate with proteinuria in human or in mouse models. These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage.

Original languageEnglish
Pages (from-to)1687-1692
Number of pages6
JournalJournal of the American Society of Nephrology : JASN
Volume20
Issue number8
DOIs
StatePublished - Aug 2009

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