Abstract
Presence of nitrotyrosine in cells surrounding plaques indicates that peroxynitrite may be the cause of brain lesions in multiple sclerosis. Low levels of uric acid, a natural scavenger of peroxynitrite, were demonstrated in blood of patients with multiple sclerosis in comparison with control individuals. These observations were now extended to 132 sets of twins one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin.
| Original language | English |
|---|---|
| Pages (from-to) | 165-166 |
| Number of pages | 2 |
| Journal | Multiple Sclerosis Journal |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
Keywords
- Autoimmunity
- Demyelinating diseases
- Inosine
- Multiple sclerosis
- Twins
- Uric acid