Uptake of the neurotransmitter candidate glutamate by glia

Fritz A. Henn, Milton N. Goldstein, Anders Hamberger

Research output: Contribution to journalArticlepeer-review

198 Scopus citations

Abstract

GLUTAMIC acid is the primary candidate for a role as an excitatory transmitter at synapses mediating the primary afferent pathway and cortical pathways in mammals1. Seeking to gain evidence for this, various laboratories have looked for a mechanism for the eflficient removal of glutamic acid from the synaptic cleft. Following the paradigm of monoamine synapses, in which high affinity uptake systems apparently localised in the presynaptic membrane remove transmitter after its action at the postsynaptic membrane 2, high affinity uptake systems for glutamate removal have been sought. Logan and Snyder3 described a high affinity transport system for glutamate in a synaptosomal preparation, and postulated that it might serve to localise glutamate-mediated synapses. Recent evidence has suggested that the transport systems involved in the removal of putative amino acid transmitters from the synaptic cleft are not localised exclusively in the synapse.

Original languageEnglish
Pages (from-to)663-664
Number of pages2
JournalNature
Volume249
Issue number5458
DOIs
StatePublished - 1974
Externally publishedYes

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