Upgrade rate of intraductal papilloma without atypia on breast core needle biopsy: A clinical, radiological and pathological correlation study

Iskender Sinan Genco, Bugra Tugertimur, Panagiotis A. Manolas, Adnan Hasanovic, Sabina Hajiyeva

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background: The aim of the study was to determine the upgrade rate on excision of intraductal papilloma (IDP) without atypia diagnosed on breast core needle biopsy (CNB). Methods: We searched our pathology department database for breast CNB with a diagnosis of IDP from 2013 to 2018. The exclusion criteria included radiologic-pathologic discordance, atypia on the same CNB, absence of histologic slides to review or absence of excision information. Upgrade was defined as ductal carcinoma in situ (DCIS) or invasive cancer identified on excision. Results: 126 IDP without atypia cases from 94 patients were identified. The upgrade rate was 1.58% (2/126). Both upgrade cases showed DCIS with low and intermediate nuclear grade. Histologic size of IDP ≥1 cm was the only statistically significant predictor factor for an upgrade on excision. Conclusion: The results suggest that non-surgical management of patients with radiologic-pathologic concordant IDP without atypia diagnosed on CNB may be appropriate in routine practice.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalAmerican Journal of Surgery
Volume220
Issue number3
DOIs
StatePublished - Sep 2020
Externally publishedYes

Keywords

  • Breast
  • Cancer
  • Core needle biopsy
  • Excision
  • Intraductal papilloma
  • Upgrade

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