Update on prostate brachytherapy: Long-term outcomes and treatment-related morbidity

Johnny Kao, Jamie A. Cesaretti, Nelson N. Stone, Richard G. Stock

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Current research in prostate brachytherapy focuses on five key concepts covered in this review. Transrectal ultrasound-guided prostate brachytherapy assisted by intraoperative treatment planning is the most advanced form of image-guided radiation delivery. Prostate brachytherapy alone for low-risk prostate cancer achieves lower prostate-specific antigen (PSA) nadirs than intensity-modulated radiotherapy (IMRT) or protons while maintaining durable biochemical control in about 90% of patients without late failures seen in surgically treated patients. As an organ-conserving treatment option, seed implant results in a lower rate of erectile dysfunction and urinary incontinence than surgery that has been validated in several recent prospective studies. Combined IMRT and seed implant has emerged as a rational and highly effective approach to radiation-dose escalation for intermediate- and high-risk prostate cancer. Preliminary results suggest that seed implantation may play a role in improving outcomes for historically poor-prognosis locally advanced and recurrent prostate cancers.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalCurrent Urology Reports
Issue number3
StatePublished - Jun 2011


  • Brachytherapy
  • Prostate cancer
  • Quality of life
  • Seed implantation


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