Update on PET glucose neuroimaging

Monte S. Buchsbaum, Erin A. Hazlett

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Positron emission tomography with 18F-deoxyglucose yields high-resolution images of brain activity with accurate quantification of a fundamental property of central nervous system function, cerebral glucose metabolic rate. Alone among brain-imaging modalities, the deoxyglucose method can be applied with microscopic resolution in animal studies, permitting detailed comparison of phamacological response in both human and non-human experiments. In schizophrenia, metabolic imaging has identified functional changes in components of the fronto-striato-thalamic circuits and the temporal lobe, and visualized changes with neuroleptic, anxiolytic and antidepressant treatment.

Original languageEnglish
Pages (from-to)339-354
Number of pages16
JournalInternational Review of Psychiatry
Issue number4
StatePublished - 1997


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