TY - JOUR
T1 - Update on Dry Eye Disease Treatment
T2 - Evidence From Randomized Controlled Trials
AU - Ucakhan, Omur O.
AU - Celik-Buyuktepe, Tuna
AU - Yang, Lin
AU - Wogu, Brian
AU - Asbell, Penny A.
N1 - Publisher Copyright:
© 2023 Lippincott Williams and Wilkins. All rights reserved.
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Although the ultimate goal of dry eye disease (DED) management is to restore the ocular surface and tear film homeostasis and address any accompanying symptoms, addressing this is not an easy task. Despite the wide range of current treatment modalities targeting multiple aspects of DED, the available DED management literature is quite heterogeneous, rendering evaluation or comparison of treatment outcomes hard or almost impossible. There is still a shortage of well-designed, large-scale, non-sponsored, randomized, controlled trials (RCTs) evaluating long-term safety and efficacy of many targeted therapies individually or used in combination, in the treatment of identified subgroups of patients with DED. This review focuses on the treatment modalities in DED management and aims to reveal the current evidence available as deduced from the outcomes of RCTs.
AB - Although the ultimate goal of dry eye disease (DED) management is to restore the ocular surface and tear film homeostasis and address any accompanying symptoms, addressing this is not an easy task. Despite the wide range of current treatment modalities targeting multiple aspects of DED, the available DED management literature is quite heterogeneous, rendering evaluation or comparison of treatment outcomes hard or almost impossible. There is still a shortage of well-designed, large-scale, non-sponsored, randomized, controlled trials (RCTs) evaluating long-term safety and efficacy of many targeted therapies individually or used in combination, in the treatment of identified subgroups of patients with DED. This review focuses on the treatment modalities in DED management and aims to reveal the current evidence available as deduced from the outcomes of RCTs.
KW - Dry eye
KW - Dry eye treatment
KW - Meibomian gland disease
KW - Ocular surface
KW - Ocular surface disease
KW - Tear film
UR - http://www.scopus.com/inward/record.url?scp=85178546049&partnerID=8YFLogxK
U2 - 10.1097/ICL.0000000000001026
DO - 10.1097/ICL.0000000000001026
M3 - Review article
C2 - 37728883
AN - SCOPUS:85178546049
SN - 1542-2321
VL - 49
SP - 542
EP - 568
JO - Eye and Contact Lens
JF - Eye and Contact Lens
IS - 12
ER -