Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Joel W. Blanchard; Li Huei Tsai

doi:10.1016/j.stem.2019.02.003

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Joel W. Blanchard, Li Huei Tsai

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.

Original language	English
Pages (from-to)	347-349
Number of pages	3
Journal	Cell Stem Cell
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2019.02.003
State	Published - 7 Mar 2019
Externally published	Yes

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10.1016/j.stem.2019.02.003

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title = "Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease",

abstract = "Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.",

author = "Blanchard, \{Joel W.\} and Tsai, \{Li Huei\}",

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T2 - New Leads in Alzheimer's Disease

AU - Blanchard, Joel W.

AU - Tsai, Li Huei

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Y1 - 2019/3/7

N2 - Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.

AB - Conflicting clinical studies have reported that statins both reduce and accelerate cognitive impairments in Alzheimer's disease. In this issue, Van der Kant et al. (2019) use iPSC-derived neurons to thoroughly dissect the link between cholesterol synthesis, phospho-Tau, and amyloid-β, revealing new therapeutic opportunities in Alzheimer's disease and related dementias.

UR - https://www.scopus.com/pages/publications/85061782765

U2 - 10.1016/j.stem.2019.02.003

DO - 10.1016/j.stem.2019.02.003

M3 - Short survey

C2 - 30849361

AN - SCOPUS:85061782765

SN - 1934-5909

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SP - 347

EP - 349

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 3

ER -

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

Abstract

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