TY - JOUR
T1 - Unintended Effects of Cardiovascular Drugs on the Pathogenesis of Alzheimer's Disease
AU - Wang, Jun
AU - Zhao, Zhong
AU - Lin, Emi
AU - Zhao, Wei
AU - Qian, Xianjuan
AU - Freire, Daniel
AU - Bilski, Amanda E.
AU - Cheng, Alice
AU - Vempati, Prashant
AU - Ho, Lap
AU - Ono, Kenjiro
AU - Yamada, Masahito
AU - Pasinetti, Giulio M.
PY - 2013/6/6
Y1 - 2013/6/6
N2 - Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while others might exacerbate, the pathogenesis of AD. We screened 1,600 FDA approved drugs for β-amyloid (Aβ)-modifying activity and identified drugs that can potentially influence amyloid precursor protein processing. In this study, we focused on cardiovascular drugs and demonstrated that some hypertensive medication can differentially modulate Aβ, both in vitro and in vivo. Our study suggests that some commonly prescribed drugs might exert unintended effects and modulate AD and provides the basis for continuing investigation of the role of individual drugs on a case-by-case basis. This line of investigation will lead to the identification of common medications that are potentially beneficial or detrimental to AD as a reference for physicians to consider when prescribing the most appropriate drugs for their patients, particularly for treating chronic disorders among the growing geriatric population.
AB - Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while others might exacerbate, the pathogenesis of AD. We screened 1,600 FDA approved drugs for β-amyloid (Aβ)-modifying activity and identified drugs that can potentially influence amyloid precursor protein processing. In this study, we focused on cardiovascular drugs and demonstrated that some hypertensive medication can differentially modulate Aβ, both in vitro and in vivo. Our study suggests that some commonly prescribed drugs might exert unintended effects and modulate AD and provides the basis for continuing investigation of the role of individual drugs on a case-by-case basis. This line of investigation will lead to the identification of common medications that are potentially beneficial or detrimental to AD as a reference for physicians to consider when prescribing the most appropriate drugs for their patients, particularly for treating chronic disorders among the growing geriatric population.
UR - http://www.scopus.com/inward/record.url?scp=84878774110&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0065232
DO - 10.1371/journal.pone.0065232
M3 - Article
C2 - 23762322
AN - SCOPUS:84878774110
SN - 1932-6203
VL - 8
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e65232
ER -