Unintended Effects of Cardiovascular Drugs on the Pathogenesis of Alzheimer's Disease

Jun Wang, Zhong Zhao, Emi Lin, Wei Zhao, Xianjuan Qian, Daniel Freire, Amanda E. Bilski, Alice Cheng, Prashant Vempati, Lap Ho, Kenjiro Ono, Masahito Yamada, Giulio M. Pasinetti

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while others might exacerbate, the pathogenesis of AD. We screened 1,600 FDA approved drugs for β-amyloid (Aβ)-modifying activity and identified drugs that can potentially influence amyloid precursor protein processing. In this study, we focused on cardiovascular drugs and demonstrated that some hypertensive medication can differentially modulate Aβ, both in vitro and in vivo. Our study suggests that some commonly prescribed drugs might exert unintended effects and modulate AD and provides the basis for continuing investigation of the role of individual drugs on a case-by-case basis. This line of investigation will lead to the identification of common medications that are potentially beneficial or detrimental to AD as a reference for physicians to consider when prescribing the most appropriate drugs for their patients, particularly for treating chronic disorders among the growing geriatric population.

Original languageEnglish
Article numbere65232
JournalPLoS ONE
Volume8
Issue number6
DOIs
StatePublished - 6 Jun 2013

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