Unilateral serous retinal detachment in a patient with thrombotic thrombocytopenic purpura

Jonathan A. Harris, Mark T. Friedman, Mala Varma

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3 Scopus citations


Ocular complications are a relatively common occurrence in patients with thrombotic thrombocytopenic purpura (TTP). Serous retinal detachment is a rare but reported complication, with most cases being bilateral and associated with concomitant hypertension. Therapeutic plasma exchange has been used to successfully treat patients with TTP. We report a case of a 46 year old woman who presented with TTP, received therapeutic plasma exchange, and developed unilateral serous retinal detachment with retinal pigment epithelial tear in the absence of reported hypertension. The increased perfusion pressure due to hypertension, combined with the choroidal vasculature damage from TTP are thought to lead to retinal epithelial tear. This suggests that although hypertension may play a role in retinal detachment in these patients, other mechanisms may be responsible.

Original languageEnglish
Pages (from-to)116-117
Number of pages2
JournalJournal of Clinical Apheresis
Issue number3
StatePublished - 2008
Externally publishedYes


  • Serous retinal detachment
  • Therapeutic plasma exchange
  • Thrombotic thrombocytopenic purpura


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