Unfolded Protein Response in Leukemia: From Basic Understanding to Therapeutic Opportunities

Ali Khateb, Ze'ev A. Ronai

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Understanding genetic and epigenetic changes that underlie abnormal proliferation of hematopoietic stem and progenitor cells is critical for development of new approaches to monitor and treat leukemia. The unfolded protein response (UPR) is a conserved adaptive signaling pathway that governs protein folding, secretion, and energy production and serves to maintain protein homeostasis in various cellular compartments. Deregulated UPR signaling, which often occurs in hematopoietic stem cells and leukemia, defines the degree of cellular toxicity and perturbs protein homeostasis, and at the same time, offers a novel therapeutic target. Here, we review current knowledge related to altered UPR signaling in leukemia and highlight possible strategies for exploiting the UPR as treatment for this disease.

Original languageEnglish
Pages (from-to)960-973
Number of pages14
JournalTrends in Cancer
Volume6
Issue number11
DOIs
StatePublished - Nov 2020
Externally publishedYes

Keywords

  • endoplasmic reticulum stress
  • hematological malignancy
  • hematopoietic stem cell
  • lymphoid leukemia
  • myeloid leukemia
  • unfolded protein response

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