TY - JOUR
T1 - Undifferentiated carcinoma of the parotid gland in a white patient
T2 - Detection of Epstein-Barr virus by in situ hybridization
AU - Kotsianti, Angeliki
AU - Costopoulos, John
AU - Morgello, Susan
AU - Papadimitriou, Constantine
PY - 1996
Y1 - 1996
N2 - Paraffin sections of an undifferentiated salivary gland carcinoma of lymphoepithelioma type, arising in a white (Greek) patient and confirmed by immunohistochemistry, were examined for the presence of Epstein-Barr virus (EBV), using in situ hybridization to detect EBV-specific EBER1 message. Epstein-Barr virus was detected in malignant epithelial cells, but was not found in lymphoid stroma or in residual benign salivary epithelium. These results confirm the existence of an association between EBV and tumor cells of undifferentiated carcinoma of parotid gland. This is die first demonstration of EBV in a salivary gland lymphoepithelioma arising in a non- Eskimo, white patient. This finding suggests that the association of EBV with undifferentiated salivary gland carcinoma may exist in geographic regions remote from Greenland.
AB - Paraffin sections of an undifferentiated salivary gland carcinoma of lymphoepithelioma type, arising in a white (Greek) patient and confirmed by immunohistochemistry, were examined for the presence of Epstein-Barr virus (EBV), using in situ hybridization to detect EBV-specific EBER1 message. Epstein-Barr virus was detected in malignant epithelial cells, but was not found in lymphoid stroma or in residual benign salivary epithelium. These results confirm the existence of an association between EBV and tumor cells of undifferentiated carcinoma of parotid gland. This is die first demonstration of EBV in a salivary gland lymphoepithelioma arising in a non- Eskimo, white patient. This finding suggests that the association of EBV with undifferentiated salivary gland carcinoma may exist in geographic regions remote from Greenland.
KW - Epstein- Barr virus
KW - in situ hybridization
KW - nasopharyngeal carcinoma
KW - salivary gland
UR - http://www.scopus.com/inward/record.url?scp=0030046862&partnerID=8YFLogxK
U2 - 10.1016/S0046-8177(96)90144-6
DO - 10.1016/S0046-8177(96)90144-6
M3 - Article
C2 - 8543318
AN - SCOPUS:0030046862
SN - 0046-8177
VL - 27
SP - 87
EP - 90
JO - Human Pathology
JF - Human Pathology
IS - 1
ER -