Understanding signaling cascades in melanoma

Pablo Lopez-Bergami, Boris Fitchman, Ze'ev Ronai

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control, metabolism, motility and the ability to escape cell death programs. Here we review the major signaling pathways currently known to be deregulated in melanoma with an implication to its development and progression. Among these pathways are Ras, B-Raf, MEK, PTEN, phosphatidylinositol-3 kinase (PI3Ks) and Akt which are constitutively activated in a significant number of melanoma tumors, in most cases due to genomic change. Other pathways discussed in this review include the [Janus kinase/signal transducer and activator of transcription (JAK/STAT), transforming growth factor-β pathways which are also activated in melanoma, although the underlying mechanism is not yet clear. As a paradigm for remodeled signaling pathways, melanoma also offers a unique opportunity for targeted drug development.

Original languageEnglish
Pages (from-to)289-306
Number of pages18
JournalPhotochemistry and Photobiology
Volume84
Issue number2
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Dive into the research topics of 'Understanding signaling cascades in melanoma'. Together they form a unique fingerprint.

Cite this