TY - JOUR
T1 - Ultrasonic Assessment of the Radius In Vitro
AU - Le Floch, Vincent
AU - Luo, Gangming
AU - Kaufman, Jonathan J.
AU - Siffert, Robert S.
N1 - Funding Information:
This project was supported by grant number R44AR054307 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The authors gratefully acknowledge the support of the Carroll and Milton Petrie Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Arthritis and Musculoskeletal and Skin Diseases or the National Institutes of Health.
PY - 2008/12
Y1 - 2008/12
N2 - The overall objective of this research is to develop an ultrasonic system for noninvasive assessment of the distal radius. The specific objective of this study was to examine the relationship between geometrical features of cortical bone and ultrasound measurements in vitro. Nineteen radii were measured in through transmission in a water bath. A 3.5 MHz rectangular (1 cm x 4.8 cm) single element transducer served as the source and a 3.5 MHz rectangular (1 cm x 4.8 cm) linear array transducer served as the receiver. The linear array consisted of 64 elements with a pitch of 0.75 mm. Ultrasound measurements were carried out at a location that was 1/3rdrd of the length from the distal end of each radius and two net time delay parameters, τNetDW and τNetCW, associated with a direct wave (DW) and a circumferential wave (CW), respectively, were evaluated. The cortical thickness (CT), medullar thickness (MT) and cross-sectional area (CSA) of each radius was also evaluated based on a digital image of the cross-section at the 1/3rd location. The linear correlations between CT and τNetDW was r = 0.91 (p < 0.001) and between MT and τNetCW - τNetDW was r = 0.63 (p < 0.05). The linear correlation between CSA and a nonlinear combination of the two net time delays, τNetDW and τNetCW, was r = 0.95 (p < 0.001). The study shows that ultrasound measurements can be used to noninvasively assess cortical bone geometrical features in vitro as represented by cortical thickness, medullar thickness and cross-sectional area. (E-mail: [email protected]).
AB - The overall objective of this research is to develop an ultrasonic system for noninvasive assessment of the distal radius. The specific objective of this study was to examine the relationship between geometrical features of cortical bone and ultrasound measurements in vitro. Nineteen radii were measured in through transmission in a water bath. A 3.5 MHz rectangular (1 cm x 4.8 cm) single element transducer served as the source and a 3.5 MHz rectangular (1 cm x 4.8 cm) linear array transducer served as the receiver. The linear array consisted of 64 elements with a pitch of 0.75 mm. Ultrasound measurements were carried out at a location that was 1/3rdrd of the length from the distal end of each radius and two net time delay parameters, τNetDW and τNetCW, associated with a direct wave (DW) and a circumferential wave (CW), respectively, were evaluated. The cortical thickness (CT), medullar thickness (MT) and cross-sectional area (CSA) of each radius was also evaluated based on a digital image of the cross-section at the 1/3rd location. The linear correlations between CT and τNetDW was r = 0.91 (p < 0.001) and between MT and τNetCW - τNetDW was r = 0.63 (p < 0.05). The linear correlation between CSA and a nonlinear combination of the two net time delays, τNetDW and τNetCW, was r = 0.95 (p < 0.001). The study shows that ultrasound measurements can be used to noninvasively assess cortical bone geometrical features in vitro as represented by cortical thickness, medullar thickness and cross-sectional area. (E-mail: [email protected]).
KW - Cortical thickness
KW - Cross-sectional area
KW - Net time delay
KW - Osteoporosis
KW - Radius
KW - Ultrasound
UR - https://www.scopus.com/pages/publications/56549092409
U2 - 10.1016/j.ultrasmedbio.2008.05.010
DO - 10.1016/j.ultrasmedbio.2008.05.010
M3 - Article
C2 - 18692295
AN - SCOPUS:56549092409
SN - 0301-5629
VL - 34
SP - 1972
EP - 1979
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 12
ER -