TY - JOUR
T1 - Ultrasonic assessment of human and bovine trabecular bone
T2 - A comparison study
AU - Alves, José M.
AU - Xu, Wei
AU - Lin, David
AU - Siffert, Robert S.
AU - Ryaby, James T.
AU - Kaufman, Jonathan J.
N1 - Funding Information:
Manuscript received February 28, 1995; revised November 17, 1995. This work was supported by OrthoLogic Corp, Phoenix, AZ, NIH under Grant lR43AR43045-01 and Conselho Nacional de Desenvolvimento Cientffico e Tecnol6gico (CNPq), Brasilia, Brazil. Asterisk indicates corresponding author. J. M. Alves is with The School of Engineering of SZo Carlos, University of SZo Paulo, Brazil. W. Xu, D. Lin, and R. S. Siffert are with Mount Sinai School of Medicine, New York, NY 10029 USA. J. T. Ryaby is with OrthoLogic Corp., Phoenix, AZ 85034 USA. *J. J. Kaufman is with the Department of Orthopaedics, The Mount Sinai Medical Center, One Gustave L. Levy Place, New York, NY 10029 USA and CyberLogic Inc., New York, NY 10012 USA (e-mail: [email protected]). Publisher Item Identifier S 0018-9294(96)01672-2.
PY - 1996
Y1 - 1996
N2 - A comparison study is reported on the ultrasonic assessment of human trabecular and bovine trabecular bone samples. Both ultrasonic velocity and ultrasonic attenuation were evaluated through a transmission insertion technique and correlated with bone mineral density as determined with single photon absorptiometry. For a 1-MHz ultrasonic transducer pair and the human cancellous bone samples the correlations were 0.91 and 0.89 between density and velocity and attenuation, respectively. For a 500-kHz ultrasonic transducer pair the correlations were 0.89 and 0.81 between density and velocity and attenuation, respectively. For the bovine bone samples, the correlations were 0.90 and -0.31 for the velocity and attenuation, respectively, for the 1 MHz transducer pair. For the 500-kHz transducers, the correlations were 0.85 and -0.17 for the velocity and attenuation, respectively. By combining both velocity and attenuation in a multivariate regression, an improvement was achieved in the estimation of bone density in the human samples for both the 500-kHz and 1-MHz transducer pairs. No significant improvement was achieved in the multivariate regressions for the bovine bone samples. In conclusion, the results indicate that ultrasonic measurements are in general highly correlated with bone mineral density in trabecular bone samples. This correlation is more consistent and strong in relatively low density human samples compared with the higher density bovine samples.
AB - A comparison study is reported on the ultrasonic assessment of human trabecular and bovine trabecular bone samples. Both ultrasonic velocity and ultrasonic attenuation were evaluated through a transmission insertion technique and correlated with bone mineral density as determined with single photon absorptiometry. For a 1-MHz ultrasonic transducer pair and the human cancellous bone samples the correlations were 0.91 and 0.89 between density and velocity and attenuation, respectively. For a 500-kHz ultrasonic transducer pair the correlations were 0.89 and 0.81 between density and velocity and attenuation, respectively. For the bovine bone samples, the correlations were 0.90 and -0.31 for the velocity and attenuation, respectively, for the 1 MHz transducer pair. For the 500-kHz transducers, the correlations were 0.85 and -0.17 for the velocity and attenuation, respectively. By combining both velocity and attenuation in a multivariate regression, an improvement was achieved in the estimation of bone density in the human samples for both the 500-kHz and 1-MHz transducer pairs. No significant improvement was achieved in the multivariate regressions for the bovine bone samples. In conclusion, the results indicate that ultrasonic measurements are in general highly correlated with bone mineral density in trabecular bone samples. This correlation is more consistent and strong in relatively low density human samples compared with the higher density bovine samples.
UR - https://www.scopus.com/pages/publications/0030111097
U2 - 10.1109/10.486282
DO - 10.1109/10.486282
M3 - Article
C2 - 8682537
AN - SCOPUS:0030111097
SN - 0018-9294
VL - 43
SP - 249
EP - 258
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 3
ER -