TY - JOUR
T1 - Ultrahigh-resolution combined coronal optical coherence tomography confocal scanning ophthalmoscope (OCT/SLO)
T2 - A pilot study
AU - Rosen, Richard B.
AU - Van Velthoven, M. E.J.
AU - Garcia, P. M.T.
AU - Cucu, R. G.
AU - De Smet, M. D.
AU - Muldoon, T. O.
AU - Podoleanu, A. Gh
PY - 2007
Y1 - 2007
N2 - Objective: To evaluate clinical images from a prototype ultrahigh resolution (UHR) combined coronal optical coherence tomography/confocal scanning ophthalmoscope (OCT/SLO) and to compare them to standard-resolution OCT/SLO images on the same patients. Design: Cross-sectional pilot-study. Participants: Sixty-six eyes of 42 patients with various macular pathologies, such as age-related macular degeneration, macular edema, macular hole, central serous retinopathy, epiretinal membrane and posterior vitreous traction syndrome. Methods: Each subject was first scanned with a standard-resolution OCT/SLO that has an axial resolution of ∼10 micron. Immediately following, patients were scanned with the prototype UHR OCT/SLO device. The UHR system employs a compact super luminescent diode (SLD) with a 150 nm bandwidth centered at 890 nm, which allows imaging of the retina with an axial resolution of 3 microns. Both coronal and longitudinal OCT scans were acquired with each system, and compared side-by-side. Scan quality was assessed for the observer's ability to visualize the vitreo-retinal interface and retinal layers - in particular of the outer retina/RPE/choroidal interface, increased discrimination of pathological changes, and better signal intensity. Main outcome measures: Ultrahigh and standard-resolution coronal and longitudinal OCT/SLO images of macular pathologies. Results: In the side-by-side comparison with the commercial standard-resolution OCT/SLO images, the scans in the Ultrahigh resolution OCT/SLO images were superior in 85% of cases. Relatively poor quality images were attributed to lower signal-to-noise ratio, limited focusing, or media opacities. Several images that had a better signal intensity in the standard-resolution OCT/SLO system were found to show more retinal detail in the UHR system. In general, intraretinal layers in the UHR OCT/SLO images were better delineated in both coronal and longitudinal scans. Enhanced details were also seen in the outer retina/RPE/choroidal complex. The UHR OCT/SLO system produced better definition of morphological changes in several macular pathologies. Conclusions: Broadband SLD-based UHR OCT/SLO offers a compact, efficient, and economic enhancement to the currently available clinical OCT imaging systems. UHR OCT/SLO imaging enhanced the quality of the OCT C-scans, facilitated appreciation of vitreo-retinal pathologies, and improved sensitivity to small changes in the retina, and the outer retina/RPE/choroidal interface.
AB - Objective: To evaluate clinical images from a prototype ultrahigh resolution (UHR) combined coronal optical coherence tomography/confocal scanning ophthalmoscope (OCT/SLO) and to compare them to standard-resolution OCT/SLO images on the same patients. Design: Cross-sectional pilot-study. Participants: Sixty-six eyes of 42 patients with various macular pathologies, such as age-related macular degeneration, macular edema, macular hole, central serous retinopathy, epiretinal membrane and posterior vitreous traction syndrome. Methods: Each subject was first scanned with a standard-resolution OCT/SLO that has an axial resolution of ∼10 micron. Immediately following, patients were scanned with the prototype UHR OCT/SLO device. The UHR system employs a compact super luminescent diode (SLD) with a 150 nm bandwidth centered at 890 nm, which allows imaging of the retina with an axial resolution of 3 microns. Both coronal and longitudinal OCT scans were acquired with each system, and compared side-by-side. Scan quality was assessed for the observer's ability to visualize the vitreo-retinal interface and retinal layers - in particular of the outer retina/RPE/choroidal interface, increased discrimination of pathological changes, and better signal intensity. Main outcome measures: Ultrahigh and standard-resolution coronal and longitudinal OCT/SLO images of macular pathologies. Results: In the side-by-side comparison with the commercial standard-resolution OCT/SLO images, the scans in the Ultrahigh resolution OCT/SLO images were superior in 85% of cases. Relatively poor quality images were attributed to lower signal-to-noise ratio, limited focusing, or media opacities. Several images that had a better signal intensity in the standard-resolution OCT/SLO system were found to show more retinal detail in the UHR system. In general, intraretinal layers in the UHR OCT/SLO images were better delineated in both coronal and longitudinal scans. Enhanced details were also seen in the outer retina/RPE/choroidal complex. The UHR OCT/SLO system produced better definition of morphological changes in several macular pathologies. Conclusions: Broadband SLD-based UHR OCT/SLO offers a compact, efficient, and economic enhancement to the currently available clinical OCT imaging systems. UHR OCT/SLO imaging enhanced the quality of the OCT C-scans, facilitated appreciation of vitreo-retinal pathologies, and improved sensitivity to small changes in the retina, and the outer retina/RPE/choroidal interface.
KW - Coronal OCT
KW - OCT ophthalmoscope
KW - OCT/SLO
KW - Ultrahigh resolution OCT
UR - http://www.scopus.com/inward/record.url?scp=33947331339&partnerID=8YFLogxK
U2 - 10.1007/s00717-007-0182-4
DO - 10.1007/s00717-007-0182-4
M3 - Article
AN - SCOPUS:33947331339
SN - 0930-4282
VL - 21
SP - 17
EP - 28
JO - Spektrum der Augenheilkunde
JF - Spektrum der Augenheilkunde
IS - 1
ER -