Juan P. Bosch, Robert Geronemus, Sheldon Glabman, George Moutoussis, Thomas Kahn, Beat von Albertini

Research output: Contribution to journalConference articlepeer-review


General remarks on the use of ultrafiltration membrane techniques in the treatment of end-stage kidney disease are kidney by a description of an experimental program in which the researchers made a comparison of hemofiltration (HF) and sequential ultrafiltration and dialysis to conventional hemodialysis (HD). It is concluded that the amino-acid changes demonstrated during HF suggest an improvement in the nutritional status of these patients. Other demonstrated changes in amino-acids may not be related to nutritional status, but may reflect better clearance of these substances. However, the lowering of the tyrosine/phenylalanine ratio due to lower levels of tyrosine may suggest a depletion syndrome. This finding may be due to losses of tyrosine by filtration or increased conversion of tyrosine to phenylalanine. In summary, the hemofiltration appears to be superior to hemodialysis in several areas, while sequential ultrafiltration and dialysis as a maintenance therapy appears to offer no clinical benefits over conventional hemodialysis and may result in the deterioration of several clinical parameters.

Original languageEnglish
Pages (from-to)523-540
Number of pages18
JournalPolymer Science and Technology
StatePublished - 1980
EventUltrafiltr Membr and Appl, Proc of the Symp at Natl Meet of ACS, 178th - Washington, DC, USA
Duration: 9 Sep 197914 Sep 1979


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