TY - JOUR
T1 - Ultra-rapid rollout vaccination with BNT162b2 to reduce SARS-CoV-2 infections in the general population
AU - Tschiderer, Lena
AU - Seekircher, Lisa
AU - Richter, Lukas
AU - von Laer, Dorothee
AU - Lass-Flörl, Cornelia
AU - Forer, Lukas
AU - Schönherr, Sebastian
AU - Krammer, Florian
AU - Embacher-Aichhorn, Sabine
AU - Tilg, Herbert
AU - Weiss, Günter
AU - Allerberger, Franz
AU - Willeit, Peter
N1 - Funding Information:
The study was supported by a grant of the Federal State of Tyrol . We are indebted to the teams of ELGA GmbH and ITSV GmbH for their invaluable work on matching and curating the study participants' data on COVID-19 vaccination from the national electronic vaccination database.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/11/18
Y1 - 2022/11/18
N2 - This study aimed to determine the impact of ultra-rapid rollout vaccination on incidence of SARS-CoV-2 infection. Vaccination with BNT162b2 was provided to 66.9% of eligible residents of the Schwaz district in Tyrol, Austria, within six days per dose (first dose: 11–16 March 2021, second dose: 8–13 April 2021). Of 11,955 individuals enrolled at nine vaccination centers (median age 44.6 years; 51.3% female), 71 had incident SARS-CoV-2 over a six-month follow-up. Incidence rates per 100,000 person-weeks were 92.3 (95% confidence interval [CI]: 70.8–120.2) at weeks 1–5 and 6.4 (3.9–10.4) at ≥6 weeks after dose 1. In these two periods, effectiveness of the vaccination campaign to reduce incident SARS-CoV-2 was 58.6% (50.8%–65.2%) and 91.1% (89.6%–92.3%) in study participants and 28.3% (23.1%–33.0%) and 64.0% (61.7%–66.1%) in the Schwaz district, compared with districts with slower vaccination rollout. Therefore, the vaccination campaign in the Schwaz district illustrates the impact of accelerated vaccination rollout in controlling the pandemic.
AB - This study aimed to determine the impact of ultra-rapid rollout vaccination on incidence of SARS-CoV-2 infection. Vaccination with BNT162b2 was provided to 66.9% of eligible residents of the Schwaz district in Tyrol, Austria, within six days per dose (first dose: 11–16 March 2021, second dose: 8–13 April 2021). Of 11,955 individuals enrolled at nine vaccination centers (median age 44.6 years; 51.3% female), 71 had incident SARS-CoV-2 over a six-month follow-up. Incidence rates per 100,000 person-weeks were 92.3 (95% confidence interval [CI]: 70.8–120.2) at weeks 1–5 and 6.4 (3.9–10.4) at ≥6 weeks after dose 1. In these two periods, effectiveness of the vaccination campaign to reduce incident SARS-CoV-2 was 58.6% (50.8%–65.2%) and 91.1% (89.6%–92.3%) in study participants and 28.3% (23.1%–33.0%) and 64.0% (61.7%–66.1%) in the Schwaz district, compared with districts with slower vaccination rollout. Therefore, the vaccination campaign in the Schwaz district illustrates the impact of accelerated vaccination rollout in controlling the pandemic.
KW - Health sciences
KW - Immunology
KW - Population
UR - http://www.scopus.com/inward/record.url?scp=85142161260&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2022.105380
DO - 10.1016/j.isci.2022.105380
M3 - Article
AN - SCOPUS:85142161260
SN - 2589-0042
VL - 25
JO - iScience
JF - iScience
IS - 11
M1 - 105380
ER -