Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice

Nicolo’ Bruschi, Giacomo Boffa, Matilde Inglese

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI provides a new tool for studying MS and other demyelinating diseases both in research and in clinical settings. We present an overview of 7-T MRI application in MS focusing on increased sensitivity and specificity for lesion detection and characterisation in the brain and spinal cord, central vein sign identification, and leptomeningeal enhancement detection. We also discuss the role of 7-T MRI in improving our understanding of MS pathophysiology with the aid of metabolic imaging. In addition, we present 7-T MRI applications in other demyelinating diseases. 7-T MRI allows better detection of the anatomical, pathological, and functional features of MS, thus improving our understanding of MS pathology in vivo. 7-T MRI also represents a potential tool for earlier and more accurate diagnosis.

Original languageEnglish
Article number59
JournalEuropean radiology experimental
Issue number1
StatePublished - 1 Dec 2020
Externally publishedYes


  • Demyelinating diseases
  • Multiple sclerosis
  • Neuromyelitis optica spectrum disorders
  • Systemic autoimmune diseases
  • Ultra-high-field magnetic resonance imaging


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