TY - JOUR
T1 - Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases
T2 - from pathology to clinical practice
AU - Bruschi, Nicolo’
AU - Boffa, Giacomo
AU - Inglese, Matilde
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI provides a new tool for studying MS and other demyelinating diseases both in research and in clinical settings. We present an overview of 7-T MRI application in MS focusing on increased sensitivity and specificity for lesion detection and characterisation in the brain and spinal cord, central vein sign identification, and leptomeningeal enhancement detection. We also discuss the role of 7-T MRI in improving our understanding of MS pathophysiology with the aid of metabolic imaging. In addition, we present 7-T MRI applications in other demyelinating diseases. 7-T MRI allows better detection of the anatomical, pathological, and functional features of MS, thus improving our understanding of MS pathology in vivo. 7-T MRI also represents a potential tool for earlier and more accurate diagnosis.
AB - Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI provides a new tool for studying MS and other demyelinating diseases both in research and in clinical settings. We present an overview of 7-T MRI application in MS focusing on increased sensitivity and specificity for lesion detection and characterisation in the brain and spinal cord, central vein sign identification, and leptomeningeal enhancement detection. We also discuss the role of 7-T MRI in improving our understanding of MS pathophysiology with the aid of metabolic imaging. In addition, we present 7-T MRI applications in other demyelinating diseases. 7-T MRI allows better detection of the anatomical, pathological, and functional features of MS, thus improving our understanding of MS pathology in vivo. 7-T MRI also represents a potential tool for earlier and more accurate diagnosis.
KW - Demyelinating diseases
KW - Multiple sclerosis
KW - Neuromyelitis optica spectrum disorders
KW - Systemic autoimmune diseases
KW - Ultra-high-field magnetic resonance imaging
UR - http://www.scopus.com/inward/record.url?scp=85093843592&partnerID=8YFLogxK
U2 - 10.1186/s41747-020-00186-x
DO - 10.1186/s41747-020-00186-x
M3 - Review article
C2 - 33089380
AN - SCOPUS:85093843592
SN - 2509-9280
VL - 4
JO - European radiology experimental
JF - European radiology experimental
IS - 1
M1 - 59
ER -