Ulcerative colitis and hemophilia A

Hemophilia A is a disease characterized by recurrent episodes of bleeding, primarily in deep soft tissue or joint spaces, due to a deficiency in levels of procoagulant activity of factor VIII. When a patient with hemophilia has a concomitant hemorrhagic disorder such as ulcerative colitis, the physician must assess which of the disorders is primary in causing a bleeding episode. We report a case of a patient with factor VIII deficiency who developed severe ulcerative colitis with major gastrointestinal bleeding.